Evaluation of Ocular Biometry in PACD With Two Swept Source Optical Coherence Tomography Devices
Study Details
Study Description
Brief Summary
Purpose: To investigate agreement between 2 swept source OCT biometers, IOL M.aster700 and Anterion, in various ocular biometry and intraocular lens (IOL) calculations of primary angle-closure disease (PACD).
Methods: This was a prospective study conducted in a tertiary eye care centre involving biometric measurements obtained with 2 devices in phakic eye with diagnosis of PACD. Mean difference and intraclass correlation coefficient (ICC) with confidence limits were assessed, and calculations of estimated residual refraction of the IOL were analysed using Barrett's formula.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Primary angle-closure disease (PACD) is the leading cause of blindness worldwide. PACD is an anatomic disorder, typically of relatively small eye with shallow anterior chamber depth (ACD), thick lens, shorter axial length (AL), small corneal curvature, and relatively anterior lens position. Pupillary block, plateau iris and phacomorphic mechanisms play major roles in the pathophysiology of the disease, and pupillary block is thought to be the most common causal mechanism.
For decades, phacoemulsification and intraocular lens implantation (PEI) has been proposed for initial management of PACD.4 PEI relieves pupillary block, deepening ACD and widening irido-corneal angle.
Biometry is essential in evaluating ocular dimensions and calculating IOL power in PACD, and ocular biometers have been evolving in recent years. Optical coherence tomography (OCT) includes partial coherence interferometry (PCI), and swept source OCT (SS-OCT) is in general use in clinical practice. The agreement of the calculations of these devices has been studied by many investigators; however, research into their agreement in PACD patients has been sparse so far. A newer SS-OCT, Anterion, is now available and its performance needs to be evaluated.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| one group compared two measurement methods one group compared two measurement methods |
Diagnostic Test: primary angle closure disease
2 swept source OCT biometers, IOL Master700 and Anterion
|
Outcome Measures
Primary Outcome Measures
- Intraclass correlation coefficient of IOL power calculation [30 minutes per person]
agreement between 2 swept source OCT biometers, IOL Master700 and Anterion, in intraocular lens (IOL) calculations
- Intraclass correlation coefficient of various ocular biometry [30 minutes per person]
agreement between 2 swept source OCT biometers, IOL Master700 and Anterion, in various ocular biometry( ACD, AL, LT, K1, K2, WTW)
Eligibility Criteria
Criteria
Inclusion Criteria:
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Inclusion criteria were age > 40 years old
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phakic eye
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diagnosis of PACD, including primary angle-closure suspect (PACS), primary angle-closure (PAC) and primary angle-closure glaucoma (PACG) as classified by Foster et al
Exclusion Criteria:
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patients who had opaque optical media
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dense cataract
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anterior and/or posterior segment diseases such as advanced pterygium, diabetic retinopathy, or maculopathy
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Participants who had previous history of ocular trauma, ocular surgery
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Somporn Chantra | Bangkok | Thailand | 10400 |
Sponsors and Collaborators
- Rajavithi Hospital
Investigators
- Principal Investigator: Somporn Chantra, MD, Rajavithi Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Rajavithi hospital