Smell&Crohn: Olfactogustatory Perception, Eating Behaviour and Inflammation in Crohn's Disease
Study Details
Study Description
Brief Summary
This study will improve our understanding of the mechanisms underlying anorexia in persons with Crohn's disease flare-ups. The practical spin-off from this research is potentially very important for the management of nutritional disorders associated with the disease by guiding diets towards foods that correspond to patients' preferences and/or to modified tastes. In addition, the results could lead to the identification of sensory markers that herald an inflammatory flare-up of the disease.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Crohn and anti-TNF treatment Tests at 3 or 4 weeks after the beginning of anti-TNF treatment |
Other: triangular test
metabolic state, impedance measurement, potential flavours evoked by sucrose,
Biological: blood sampling
sampling of 2 mL
Other: Questionnaires
Stunkard, PrefQuest
|
| Crohn and without anti-TNF treatment tests performed according to patient availability |
Other: triangular test
metabolic state, impedance measurement, potential flavours evoked by sucrose,
Biological: blood sampling
sampling of 2 mL
Other: Questionnaires
Stunkard, PrefQuest
|
| Control tests performed according to patient availability |
Other: triangular test
metabolic state, impedance measurement, potential flavours evoked by sucrose,
Biological: blood sampling
sampling of 2 mL
Other: Questionnaires
Stunkard, PrefQuest
|
Outcome Measures
Primary Outcome Measures
- Modification of sweet taste [through the study completion up to 10 years]
the measurement of detection thresholds consists in presenting to the participants in order of increasing concentrations, series of forced-choice triangular tests
Eligibility Criteria
Criteria
For patients :
Inclusion Criteria:
-
Age between 18 and 60 years,
-
Diagnosis of Crohn's disease according to clinical, endoscopic, histological, radiological and biochemical criteria as defined by the European Consensus Conference,
-
Men or women who have provided consent and willing to cooperate.
Exclusion Criteria:
-
Chronic inflammatory intestinal disease (CIID) other than Crohn's disease: haemorrhagic rectocolitis, undetermined colitis, microscopic colitis.
-
Intercurrent disease (diabetes and metabolic disease, liver cirrhosis, progressive cancer, acute or chronic infection, Human Immunodeficiency Virus HIV),
-
Organ failure (respiratory, heart, or renal failure, neurological disorders),
-
Intolerance to gluten,
-
Treatments (other than those used for Crohn's disease) able to interfere with food intake,
-
Aversion to foods consumed or smelled,
-
Poor understanding of cognitive tasks required.
-
Crohn's disease complicated by an abscess or infectious complication
-
Acute Crohn's disease defined by a CDAI score > 150
For Controls:
Inclusion Criteria:
-
Adult person
-
Without follow-up for a chronic pathology
-
Having given its consent
Exclusion Criteria:
-
Protected adult
-
Person not affiliated to a social security system
-
Pregnant or breastfeeding woman
-
Active smoker
-
No one who does not speak French
-
Taking treatment that interferes with taste or acts on the central nervous system
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Centre Hospitalier Universitaire | Dijon | France | 21079 |
Sponsors and Collaborators
- Centre Hospitalier Universitaire Dijon
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- BRONDEL Ass INRA 2011