Positive End-expiratory Pressure and Alveolar Recruitment for One Lung Ventilation

• Sponsor: Yonsei University (Other)
• Overall Status: Completed
• CT.gov ID: NCT01652612
• Collaborator: (none)
• Enrollment: 99
• Location: 1
• Arms: 3
• Duration (Months): 18.1
• Patients Per Site Per Month: 5.5

Study Details

Study Description

Brief Summary

Hypoxia frequently develops during one lung ventilation in the supine position.The objective of this article is to study the impact of preemptive alveolar recruitment and subsequent positive end expiratory pressure on arterial oxygenation and lung mechanics during one lung ventilation in the supine position in patients undergoing thoracic surgery .

Condition or Disease	Intervention/Treatment	Phase
One Lung Ventilation	Other: PEEP	N/A

Detailed Description

outcome measures: respiratory parameters (Paw, Ppla, Compliance, Vd/Vt)and oxygenation parameters (PaO2, shunt fraction, Pa-AO2)

Study Design

• Study Type: Interventional
• Actual Enrollment: 99 participants
• Allocation: Randomized
• Intervention Model: Single Group Assignment
• Masking: Double (Participant, Care Provider)
• Primary Purpose: Prevention
• Official Title: Effects of Positive End-expiratory Pressure and Alveolar Recruitment on the Oxygenation and Respiratory Mechanics During One-lung Ventilation in the Supine Position
• Study Start Date: Aug 1, 2011
• Actual Primary Completion Date: Feb 1, 2013
• Actual Study Completion Date: Feb 1, 2013

Arms and Interventions

Arm	Intervention/Treatment
No Intervention: Control zero PEEP
Experimental: OLV strategy: PEEP 1. apply 8 cm H2O positive end expiratory pressure during one lung ventilation and until the end of surgery	Other: PEEP; 8 cmH2O PEEP throughout the period of OLV and 2nd TLV
Experimental: OLV strategy: PEEP followed by AR alveolar recruitment strategy before one lung ventilation 8 cmH2O positive end expiratory pressure during one lung ventilation and until the end of surgery	Other: PEEP; 8 cmH2O PEEP throughout the period of OLV and 2nd TLV

Outcome Measures

Primary Outcome Measures

1. PaO2, number of patients with hypoxia (PaO2< 90mmHg) [participants will be followed for the duration of anesthesia, an expected average of 3 hours]

   blood samplings after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV

Secondary Outcome Measures

1. intrapulmonary shunt [participants will be followed for the duration of anesthesia, an expected average of 3 hours]

   blood sampling after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV

Eligibility Criteria

Criteria

• Ages Eligible for Study: 20 Years to 75 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• ASA I-II

• age: 20-75 years

Exclusion Criteria:

• moderate to severe impaired respiratory function,

• heart failure,

• patients' refusal

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Yong Seon Choi	Seoul		Korea, Republic of

Sponsors and Collaborators

• Yonsei University

Investigators

• Principal Investigator: Yongseon Choi, Assistant professor

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Yongseon Choi, assistant professor, Yonsei University
• ClinicalTrials.gov Identifier: NCT01652612
• Other Study ID Numbers: 4-2011-0301
• First Posted: Jul 30, 2012
• Last Update Posted: Jul 4, 2013
• Last Verified: Jul 1, 2013

• Keywords provided by Yongseon Choi, assistant professor, Yonsei University: positive end expiratory pressure

Study Results

No Results Posted as of Jul 4, 2013