180 Degree vs. 360 Degree Selective Laser Trabeculoplasty as Initial Therapy for Glaucoma

• Sponsor: Temple University (Other)
• Overall Status: Completed
• CT.gov ID: NCT02628223
• Collaborator: (none)
• Enrollment: 76
• Locations: 2
• Arms: 2
• Duration (Months): 39
• Patients Per Site: 38
• Patients Per Site Per Month: 1

Study Details

Study Description

Brief Summary

Selective laser trabeculoplasty (SLT) is a well-recognized way to lower eye pressure in treatment of glaucoma. This treatment is performed for 180 degrees or 360 degrees, and studies at academic centers have shown mixed results when comparing the success rates of 180 degrees or 360 degrees. Both protocols are now typically done by comprehensive ophthalmologists. However, there is no data that compares success rates of 180 degrees and 360 degrees in the community setting.

Condition or Disease	Intervention/Treatment	Phase
Open Angle Glaucoma; Ocular Hypertension; Glaucoma, Open Angle, Pseudo-exfoliative; Pigment Dispersion Syndrome; Glaucoma	Procedure: Selective Laser Trabeculoplasty; Device: Neodymium:Yttrium Aluminum Garnet (YAG) laser	N/A

Detailed Description

This study is designed as a prospective evaluation of the two treatment algorithms for SLT by measuring intraocular pressure (IOP) after treatment. The hypothesis is that 360 degrees of SLT will produce a greater reduction in IOP than 180 degrees of SLT at 3 months follow up.

Study Design

• Study Type: Interventional
• Actual Enrollment: 76 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Single (Investigator)
• Primary Purpose: Treatment
• Official Title: A Randomized Trial of 180 Degree vs. 360 Degree Selective Laser Trabeculoplasty as Initial Therapy for Glaucoma
• Study Start Date: Sep 1, 2014
• Actual Primary Completion Date: Dec 1, 2017
• Actual Study Completion Date: Dec 1, 2017

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: 180 degrees 180 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser	Procedure: Selective Laser Trabeculoplasty; The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.; Other Names: SLT ; Device: Neodymium:Yttrium Aluminum Garnet (YAG) laser; The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.; Other Names: Nd:YAG laser
Active Comparator: 360 degrees 360 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser	Procedure: Selective Laser Trabeculoplasty; The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.; Other Names: SLT ; Device: Neodymium:Yttrium Aluminum Garnet (YAG) laser; The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.; Other Names: Nd:YAG laser

Outcome Measures

Primary Outcome Measures

1. Intraocular Pressure (IOP) Measured by Tonometry in Millimeters of Mercury at Three Months of Follow-up [3 months]

   Intraocular pressure (IOP) measured by tonometry in millimeters of mercury at three months of follow-up

Secondary Outcome Measures

1. Intraocular Pressure (IOP) Measured by Tonometry in Millimeters of Mercury at 1 Year of Follow-up [1 year]

   Intraocular pressure (IOP) measured by tonometry in millimeters of mercury at 1 year of follow-up

2. Intraocular Pressure (IOP) Measured by Tonometry in Millimeters of Mercury at Time at Which Additional Glaucoma Therapy is Required [within 1 year of study intervention]

   Intraocular pressure (IOP) measured by tonometry in millimeters of mercury at time at which additional glaucoma therapy is required

3. Intraocular Pressure (IOP) Measured by Tonometry in Millimeters of Mercury at Last Follow-up [within 1 year of study intervention]

   Intraocular pressure (IOP) measured by tonometry in millimeters of mercury at last follow-up

Other Outcome Measures

1. Number of Participants With Intraocular Pressure (IOP) Spike Assessed by Tonometry [within 1 year of study intervention]

   If IOP spike occurs, it will be treated accordingly.

2. Number of Participants With Trabeculitis Assessed by Ophthalmic Exam and Gonioscopy [within 1 year of study intervention]

   If trabeculitis occurs, it will be treated accordingly.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• patients who have been diagnosed with open-angle glaucoma including ocular hypertension, pseudoexfoliation and pigment dispersion syndrome

• greater than 18 years of age

• initial intraocular pressure (IOP) of ≥ 21 mmHg

Exclusion Criteria:

• prior medical or laser therapy to lower IOP

• previous incisional glaucoma surgery before the study period

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Brandywine Eye Center	Wilmington	Delaware	United States	19810
2	Levin Luminais Chronister Eye Associates	Thorndale	Pennsylvania	United States	19372

Sponsors and Collaborators

• Temple University

Investigators

• Principal Investigator: Jeffrey D. Henderer, MD, Temple University
• Study Director: Sophia Siu, MD, Temple University

Study Documents (Full-Text)

• Study Protocol and Statistical Analysis Plan - Nov 13, 2016

More Information

Publications

None provided.

• Responsible Party: Temple University
• ClinicalTrials.gov Identifier: NCT02628223
• Other Study ID Numbers: 21921
• First Posted: Dec 11, 2015
• Last Update Posted: Nov 5, 2020
• Last Verified: Nov 1, 2020

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No
• Keywords provided by Temple University: glaucoma; Elevated IOP; Selective Laser Trabeculoplasty; SLT; open angle glaucoma; ocular hypertension; Glaucoma, Open Angle, Pseudo-exfoliative; pigment dispersion syndrome; Pseudoexfoliation; IOP ≥ 21 mmHg
• Additional relevant MeSH terms: Glaucoma; Glaucoma, Open-Angle; Ocular Hypertension; Hypertension

Study Results

Participant Flow

Arm/Group Title	180 Degrees	360 Degrees
Arm/Group Description	180 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.	360 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.
Period Title: Overall Study
STARTED	38	38
COMPLETED	38	36
NOT COMPLETED	0	2

Baseline Characteristics

Arm/Group Title	180 Degrees	360 Degrees	Total
Arm/Group Description	180 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.	360 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.	Total of all reporting groups
Overall Participants	38	38	76
Age (Count of Participants)
<=18 years	0 0%	0 0%	0 0%
Between 18 and 65 years	9 23.7%	5 13.2%	14 18.4%
>=65 years	29 76.3%	33 86.8%	62 81.6%
Age (years) [Mean (Standard Deviation) ]
Mean (Standard Deviation) [years]	71.4 (8.6)	71.9 (6.7)	71.6 (7.7)
Sex: Female, Male (Count of Participants)
Female	19 50%	20 52.6%	39 51.3%
Male	19 50%	18 47.4%	37 48.7%
Race (NIH/OMB) (Count of Participants)
American Indian or Alaska Native	0 0%	0 0%	0 0%
Asian	0 0%	0 0%	0 0%
Native Hawaiian or Other Pacific Islander	0 0%	0 0%	0 0%
Black or African American	4 10.5%	8 21.1%	12 15.8%
White	32 84.2%	28 73.7%	60 78.9%
More than one race	1 2.6%	2 5.3%	3 3.9%
Unknown or Not Reported	1 2.6%	0 0%	1 1.3%
Hypertension (Count of Participants)
Count of Participants [Participants]	25 65.8%	29 76.3%	54 71.1%
Diabetes (Count of Participants)
Count of Participants [Participants]	9 23.7%	14 36.8%	23 30.3%
Glaucoma (mild, moderate, severe, indeterminant) (Count of Participants)
Mild	13 34.2%	12 31.6%	25 32.9%
Moderate	4 10.5%	8 21.1%	12 15.8%
Severe	1 2.6%	2 5.3%	3 3.9%
Indeterminant	7 18.4%	0 0%	7 9.2%
No Glaucoma	13 34.2%	16 42.1%	29 38.2%
Ocular Hypertension (Count of Participants)
Count of Participants [Participants]	8 21.1%	12 31.6%	20 26.3%
Pseudoexfoliation (Count of Participants)
Count of Participants [Participants]	6 15.8%	1 2.6%	7 9.2%
Pigment Dispersion Syndrome (Count of Participants)
Count of Participants [Participants]	0 0%	0 0%	0 0%

Outcome Measures

1. Primary Outcome

Title	Intraocular Pressure (IOP) Measured by Tonometry in Millimeters of Mercury at Three Months of Follow-up
Description	Intraocular pressure (IOP) measured by tonometry in millimeters of mercury at three months of follow-up
Time Frame	3 months

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title	180 Degrees	360 Degrees
Arm/Group Description	180 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.	360 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.
Measure Participants	38	36
Mean (Standard Deviation) [mm Hg]	20.7 (5.4)	19.1 (4.1)

2. Secondary Outcome

Title	Intraocular Pressure (IOP) Measured by Tonometry in Millimeters of Mercury at 1 Year of Follow-up
Description	Intraocular pressure (IOP) measured by tonometry in millimeters of mercury at 1 year of follow-up
Time Frame	1 year

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title	180 Degrees	360 Degrees
Arm/Group Description	180 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.	360 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.
Measure Participants	38	36
Mean (Standard Deviation) [mm Hg]	18.7 (3.1)	19.0 (4.4)

3. Secondary Outcome

Title	Intraocular Pressure (IOP) Measured by Tonometry in Millimeters of Mercury at Time at Which Additional Glaucoma Therapy is Required
Description	Intraocular pressure (IOP) measured by tonometry in millimeters of mercury at time at which additional glaucoma therapy is required
Time Frame	within 1 year of study intervention

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title	180 Degrees	360 Degrees
Arm/Group Description	180 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.	360 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.
Measure Participants	38	36
Mean (Standard Deviation) [mm Hg]	24.7 (4.0)	23.7 (3.3)

4. Secondary Outcome

Title	Intraocular Pressure (IOP) Measured by Tonometry in Millimeters of Mercury at Last Follow-up
Description	Intraocular pressure (IOP) measured by tonometry in millimeters of mercury at last follow-up
Time Frame	within 1 year of study intervention

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title	180 Degrees	360 Degrees
Arm/Group Description	180 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.	360 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.
Measure Participants	38	36
Mean (Standard Deviation) [mm Hg]	18.2 (2.8)	18.3 (4.9)

5. Other Pre-specified Outcome

Title	Number of Participants With Intraocular Pressure (IOP) Spike Assessed by Tonometry
Description	If IOP spike occurs, it will be treated accordingly.
Time Frame	within 1 year of study intervention

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title	180 Degrees	360 Degrees
Arm/Group Description	180 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.	360 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.
Measure Participants	38	36
Count of Participants [Participants]	0 0%	0 0%

6. Other Pre-specified Outcome

Title	Number of Participants With Trabeculitis Assessed by Ophthalmic Exam and Gonioscopy
Description	If trabeculitis occurs, it will be treated accordingly.
Time Frame	within 1 year of study intervention

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title	180 Degrees	360 Degrees
Arm/Group Description	180 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.	360 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.
Measure Participants	38	36
Count of Participants [Participants]	0 0%	0 0%

Adverse Events

Time Frame	1 year
Arm/Group Title	180 Degrees		360 Degrees
Arm/Group Description	180 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.		360 degrees of Selective Laser Trabeculoplasty using Neodymium:Yttrium Aluminum Garnet (YAG) laser Selective Laser Trabeculoplasty: The procedure uses light energy provided by a neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp. Neodymium:Yttrium Aluminum Garnet (YAG) laser: The procedure uses a 400 μm spot size of light energy provided by a low-energy, Q-switched, frequency-doubled (532 nm) neodymium (Nd):Yttrium Aluminum Garnet (YAG) laser with a short pulse duration of 3 nanoseconds that is directed into the iridocorneal angle via a goniolens viewed through a standard slit lamp.
All Cause Mortality
	180 Degrees		360 Degrees
	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events
Total	0/38 (0%)		0/36 (0%)
Serious Adverse Events
	180 Degrees		360 Degrees
	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events
Total	0/38 (0%)		0/36 (0%)
Other (Not Including Serious) Adverse Events
	180 Degrees		360 Degrees
	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events
Total	0/38 (0%)		1/36 (2.8%)
Eye disorders
Corneal Abrasian	0/38 (0%)	0	1/36 (2.8%)	1

Limitations/Caveats

There were some limitations to this study that include: No standardized definition of who needed laser; No standardized technique other than the amount of meshwork lasered; No standardized IOP checking device; No standardized post op drop regimen; No standardized follow up interval.

More Information

Certain Agreements

All Principal Investigators ARE employed by the organization sponsoring the study.

There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed.