PDT vs PT: Phaco-Trabeculotomy Vs Phaco-Trabeculectomy
Study Details
Study Description
Brief Summary
A prospective, randomized comparative study on adult patients with synechial angle closure glaucoma.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Patients were randomized into two groups: group A : patients will undergo two site phacoemulfication combined with trabeculectomy Group B with Phacoemulsification combined with ab-externo trabeculotomy. Preoperative assessments including full ophthalmic examination, anterior segment Optical Coherence Tomography (OCT) of the angle , endothelial cell count , visual fiend Perimetry and Biometry. Patients were followed up: first day, first week and every two months for 6 month. We will compare adverse effects and outcomes in both groups.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Phacoemulsification combined with trabeculectomy Patients will undergo Two site phacoemulsification combined with trabeculectomy with Mitomycin C |
Procedure: Phacoemulsification combined with trabeculectomy
Patients with chronic angle closure glaucoma assigned to this group will have fornex based trabeculectomy at superior limbus and then phacoemulsification via temporal incision
|
| Active Comparator: Phacoemulsificaiton combined with ab-externo trabeculotomy Patients will undergo two phacoemulsification combined with deep sclerectomy and ab-externo trabeculotomy |
Procedure: Phacoemulsificaiton combined with ab-externo trabeculotomy
Patients with chronic angle closure glaucoma assigned to this group will have Deep Sclerectomy with ab externo trabeculotomy at superior limbus and then phacoemulsification via temporal incision
|
Outcome Measures
Primary Outcome Measures
- Absolute Success [1,3,6 months]
Reduction of IOP more than 30% on no glaucoma drops
- Visual outcome [1,3,6 month]
Uncorrected visual acuity by Snellen's chart
Secondary Outcome Measures
- Adverse events [1 week, 1 month, 3 months, 6 months]
all intraoperative and postoperative adverse events witt be recorded
Eligibility Criteria
Criteria
Inclusion Criteria:
Patients with chronic angle closure glaucoma, with or without peripheral anterior synechiae, age more than 18
Exclusion Criteria:
-
Patient unable for follow up
-
Patients with corneal or retinal disease that affects visual outcome of surgery
-
Patients with previous glaucoma procedure in the eye of study
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Assiut University Hospital | Assiut | Egypt | 7125 |
Sponsors and Collaborators
- Assiut University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Hansapinyo L, Choy BNK, Lai JSM, Tham CC. Phacoemulsification Versus Phacotrabeculectomy in Primary Angle-closure Glaucoma With Cataract: Long-Term Clinical Outcomes. J Glaucoma. 2020 Jan;29(1):15-23. doi: 10.1097/IJG.0000000000001397.
- Lichter PR, Musch DC, Gillespie BW, Guire KE, Janz NK, Wren PA, Mills RP; CIGTS Study Group. Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery. Ophthalmology. 2001 Nov;108(11):1943-53.
- Rebolleda G, Muñoz-Negrete FJ. Phacoemulsification in eyes with functioning filtering blebs: a prospective study. Ophthalmology. 2002 Dec;109(12):2248-55.
- Töteberg-Harms M, Wachtl J, Schweier C, Funk J, Kniestedt C. Long-term efficacy of combined phacoemulsification plus trabeculectomy versus phacoemulsification plus excimer laser trabeculotomy. Klin Monbl Augenheilkd. 2017 Apr;234(4):457-463. doi: 10.1055/s-0043-100291. Epub 2017 Mar 6.
- IRB17300506