Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease

Sponsor

Case Comprehensive Cancer Center (Other)

Overall Status

Withdrawn

CT.gov ID

NCT00733252

Collaborator

National Cancer Institute (NCI) (NIH)

Enrollment

Location

Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

RATIONALE: Diagnostic procedures, such as optical coherence tomography, may help find and diagnose lung cancer or precancerous cells.

PURPOSE: This phase I trial is studying how well optical coherence tomography of the airway works in detecting abnormal cells in patients undergoing surgery for lung cancer or lung disease.

Condition or Disease	Intervention/Treatment	Phase
Lung Cancer Malignant Mesothelioma Metastatic Cancer Nonmalignant Neoplasm Precancerous Condition	Procedure: bronchoscopic and lung imaging studies Procedure: diagnostic bronchoscopy Procedure: histopathologic examination Procedure: optical coherence tomography

Detailed Description

OBJECTIVES:

Correlate optical coherence tomography images of the airway with airway histology.
Develop an imaging technique to detect premalignant airway epithelial changes (carcinoma in situ, dysplasia) to study the transformation process as well as intervene and prevent the development of lung cancer.

OUTLINE: Bronchoscopic imaging and optical coherence tomography are performed on lung tissue samples collected during surgery. All imaged areas are marked. The marked areas are then excised and fixed in formalin for histopathologic analysis.

Study Design

Study Type:

Observational

Actual Enrollment :

0 participants

Observational Model:

Case-Only

Time Perspective:

Retrospective

Official Title:

Optical Coherence Tomography of Human Airways

Study Start Date :

Apr 1, 2008

Actual Primary Completion Date :

Jan 1, 2011

Actual Study Completion Date :

Feb 1, 2011

Outcome Measures

Primary Outcome Measures

Correlation of optical coherence tomography images of the airway with airway histology [This study will involve discarded tissue from 10 subjects with pathology specimens over one year.]