RAO-OCTA: Optical Coherence Tomography Angiography Examinations in Chronic Retinal Artery Occlusion
Study Details
Study Description
Brief Summary
Purpose of the study is to examine the retinal blood flow in chronic cases of retinal artery occlusion with non-invasive, non-contact optical coherence tomography angiography.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Occlusion of the retinal arteries is an emergency which causes sudden, painless unilateral vision loss. Loss of blood flow causes ischemic damage to the retina. The extent of damage depends on the area affected.
Following the acute phase of the disease re-canalization occurs and lesser blood flow can be detected usually without functional recovery.
Purpose of the study is to examine the retinal blood flow in chronic cases of retinal artery occlusion.
Standard procedures to examine this disease include retinoscopy following pupil dilation, fluorescein angiography and more recently, optical coherence tomography (OCT).
The latest direction in OCT development was OCT angiography (OCTA) which is a software upgrade that allows detection of blood flow based on motion contrast. Similar to previous OCT machines OCTA is also non-invasive and non-contact and does not require any intravenous agents.
OCT machines are approved in the EU and the US and are not experimental devices.
The device used in this study is the commercially available Zeiss Cirrus HD OCT Angioplex 5000 that operates with spectral-domain technology.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| CRA Patients with chronic retinal artery occlusion |
Device: Optical coherence tomography angiography
OCTA scans per built-in device protocol
|
| Control Healthy |
Device: Optical coherence tomography angiography
OCTA scans per built-in device protocol
|
Outcome Measures
Primary Outcome Measures
- Capillary density in relation to healthy subjects [Through study completion, 1 year]
Secondary Outcome Measures
- Correlation of capillary density and retinal thickness [Through study completion, 1 year]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
central or branch retinal artery occlusion
-
at least 6 months of onset
-
signed informed consent
Exclusion Criteria:
-
known epilepsy
-
incapacity
-
presence of optical media opacities that would disturb the imaging
-
presence of other retinal diseases that would disturb the evaluation of images
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Semmelweis University, Department of Ophthalmology | Budapest | Hungary | 1085 |
Sponsors and Collaborators
- Semmelweis University
Investigators
- Principal Investigator: Miklos Schneider, Semmelweis University, Department of Ophthalmology
Study Documents (Full-Text)
None provided.More Information
Publications
- Bonini Filho MA, Adhi M, de Carlo TE, Ferrara D, Baumal CR, Witkin AJ, Reichel E, Kuehlewein L, Sadda SR, Sarraf D, Duker JS, Waheed NK. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN RETINAL ARTERY OCCLUSION. Retina. 2015 Nov;35(11):2339-46. doi: 10.1097/IAE.0000000000000850.
- Chalam KV, Sambhav K. Optical Coherence Tomography Angiography in Retinal Diseases. J Ophthalmic Vis Res. 2016 Jan-Mar;11(1):84-92. doi: 10.4103/2008-322X.180709. Review.
- Jia Y, Bailey ST, Hwang TS, McClintic SM, Gao SS, Pennesi ME, Flaxel CJ, Lauer AK, Wilson DJ, Hornegger J, Fujimoto JG, Huang D. Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye. Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2395-402. doi: 10.1073/pnas.1500185112. Epub 2015 Apr 20.
- Samara WA, Say EA, Khoo CT, Higgins TP, Magrath G, Ferenczy S, Shields CL. CORRELATION OF FOVEAL AVASCULAR ZONE SIZE WITH FOVEAL MORPHOLOGY IN NORMAL EYES USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. Retina. 2015 Nov;35(11):2188-95. doi: 10.1097/IAE.0000000000000847.
- Savastano MC, Lumbroso B, Rispoli M. IN VIVO CHARACTERIZATION OF RETINAL VASCULARIZATION MORPHOLOGY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. Retina. 2015 Nov;35(11):2196-203. doi: 10.1097/IAE.0000000000000635.
- Spaide RF. VOLUME-RENDERED ANGIOGRAPHIC AND STRUCTURAL OPTICAL COHERENCE TOMOGRAPHY. Retina. 2015 Nov;35(11):2181-7. doi: 10.1097/IAE.0000000000000764.
- Yu S, Lu J, Cao D, Liu R, Liu B, Li T, Luo Y, Lu L. The role of optical coherence tomography angiography in fundus vascular abnormalities. BMC Ophthalmol. 2016 Jul 13;16:107. doi: 10.1186/s12886-016-0277-2.
- RAO-OCTA-1253