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OPT-IRM: OPTIMIZATION of ADVANCED MR SEQUENCES

Sponsor
Centre Hospitalier St Anne (Other)
Overall Status
Recruiting
CT.gov ID
NCT05618990
Collaborator
(none)
300
Enrollment
1
Location
73
Anticipated Duration (Months)
4.1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This monocentric methodological study aims at optimizing advanced MR sequences for image quality (reduced artefacts, signal to noise ratio, acquisition time, stability of quantitative measurements) on a new MR unit dedicated to research in clinical and cognitive neuroscience.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Primary goal : Optimization of MR protocols and validation of acquisition parameters of advanced MR sequences on healthy volunteers or patients on a new 3T MR unit dedicated to research in neurosciences.

    Secondary goals

    1. Perform acquisitions to validate the feasibility of research MR protocols (pilot subjects)

    2. reproducibility studies

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    300 participants
    Observational Model:
    Cohort
    Time Perspective:
    Other
    Official Title:
    OPTIMIZATION of AVANCED MR SEQUENCES for BRAIN STUDIES in VOLUNTEERS (HEALTHY and PATIENTS)
    Actual Study Start Date :
    Nov 5, 2019
    Anticipated Primary Completion Date :
    Nov 5, 2025
    Anticipated Study Completion Date :
    Dec 5, 2025

    Outcome Measures

    Primary Outcome Measures

    1. MR sequences optimization [72 months]

      Optimization of MR protocols and validation of acquisition parameters of advanced MR sequences on healthy volunteers or patients on a new 3T MR unit dedicated to research in neurosciences. Outcome measures depend on each pulse optimized sequence (signal-to-noise ratio, contrast-to-noise ratio, quantitative MR biomarkers).

    Secondary Outcome Measures

    1. Reproducibility studies [72 months]

      Reproducibility studies (quantitative parameters, effect of denoising ...). Outcome measures depend on each pulse optimized sequence (artifacts, signal-to-noise ratio, contrast-to-noise ratio, quantitative MR biomarkers).

    2. Pilot studies [72 months]

      Feasibility studies in cognitive neurosciences. Outcome measures depend on each MR protocol (artifacts, signal-to-noise ratio, contrast-to-noise ratio, quantitative MR biomarkers).

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • 18 ans

    • Covered by social security

    • For women in age of procreation, under efficient contraception

    • Written consent

    Exclusion Criteria:

    • Any MR contraindication

    • Claustrophobia

    • Pregnancy

    • Under judiciary protection

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 OPPENHEIM Catherine Paris France 75014

    Sponsors and Collaborators

    • Centre Hospitalier St Anne

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Centre Hospitalier St Anne
    ClinicalTrials.gov Identifier:
    NCT05618990
    Other Study ID Numbers:
    • D19-P005
    First Posted:
    Nov 16, 2022
    Last Update Posted:
    Nov 22, 2022
    Last Verified:
    Sep 1, 2022
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Mental Disorders

    Study Results

    No Results Posted as of Nov 22, 2022