Oral Antibiotic Bowel Preparation in Gynecologic Oncology Surgery
Study Details
Study Description
Brief Summary
The purpose of this study is to investigate whether the use of a preoperative antibiotic bowel regimen is associated with a reduced risk of deep organ/space surgical site infection in gynecologic oncology surgery.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
This is a retrospective chart review study. Patients who underwent scheduled intra-abdominal surgery with a WellSpan gynecologic oncologist will be identified and their chart reviewed for demographic data of age, race, BMI, comorbidities, and type of surgery. Those patients who had a deep organ/space surgical site infection within 30 days postoperatively will be identified. The numbers of these infections before and after August 2020, at which time all patients moving forwards were prescribed antibiotic bowel preparation, will then be statistically analyzed and compared to see if the institution of the antibiotic bowel preparation was associated with a reduction in surgical site infection.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| No Antibiotic Bowel Prep Patients who did not receive a preoperative antibiotic bowel preparation |
Other: Diagnosed with Surgical Site Infection
As an observational study, this notates patients who were diagnosed with a deep organ/space surgical site infection within 30 days of surgery
|
| Antibiotic Bowel Prep Patients who did receive a preoperative antibiotic bowel preparation |
Outcome Measures
Primary Outcome Measures
- Surgical Site Infection Rates Associated with Antibiotic Bowel Prep [2019-2021]
Rate of surgical site infection rate as associated with or without use of antibiotic bowel preparation
Eligibility Criteria
Criteria
Inclusion Criteria:
- Underwent scheduled intra-abdominal surgery with a WellSpan gynecologic oncologist
Exclusion Criteria:
-
Unscheduled surgery
-
Intraoperative consult by a WellSpan gynecologic oncologist
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | WellSpan | York | Pennsylvania | United States | 17403 |
Sponsors and Collaborators
- WellSpan Health
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Kalogera E, Van Houten HK, Sangaralingham LR, Borah BJ, Dowdy SC. Use of bowel preparation does not reduce postoperative infectious morbidity following minimally invasive or open hysterectomies. Am J Obstet Gynecol. 2020 Aug;223(2):231.e1-231.e12. doi: 10.1016/j.ajog.2020.02.035. Epub 2020 Feb 26.
- Morris MS, Graham LA, Chu DI, Cannon JA, Hawn MT. Oral Antibiotic Bowel Preparation Significantly Reduces Surgical Site Infection Rates and Readmission Rates in Elective Colorectal Surgery. Ann Surg. 2015 Jun;261(6):1034-40. doi: 10.1097/SLA.0000000000001125.
- Nelson RL, Glenny AM, Song F. Antimicrobial prophylaxis for colorectal surgery. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD001181. doi: 10.1002/14651858.CD001181.pub3. Review. Update in: Cochrane Database Syst Rev. 2014;5:CD001181.
- Nichols RL, Broido P, Condon RE, Gorbach SL, Nyhus LM. Effect of preoperative neomycin-erythromycin intestinal preparation on the incidence of infectious complications following colon surgery. Ann Surg. 1973 Oct;178(4):453-62.
- 1847220-1