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The Role of microRNA-29b in the Oral Squamous Cell Carcinoma

Sponsor
National Taiwan University Hospital (Other)
Overall Status
Unknown status
CT.gov ID
NCT02009852
Collaborator
(none)
100
Enrollment
1
Location

Study Details

Study Description

Brief Summary

The Role of microRNA-29b in the Oral Squamous Cell Carcinoma

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    To find out if there is prognostic value which to the performance of microRNA-29b of oral cancer in Taiwan and provide some reference for future treatment.

    We anticipate to enroll 100 persons with oral cancer and collect the tissue which was stained for pathological sections over a 3 year period.

    We also collect the blood and saliva samples from patients and the results along with patient-specific information such as tumor phases, tumor size, lymph node metastasis, cancer metastasis, prognosis and betel nut chewing, smoking and drinking habits and other parameters are statistically analyzed.

    Study Design

    Study Type:
    Observational [Patient Registry]
    Anticipated Enrollment :
    100 participants
    Observational Model:
    Case-Only
    Official Title:
    The Role of microRNA-29b in the Oral Squamous Cell Carcinoma
    Study Start Date :
    Jan 1, 2014
    Anticipated Primary Completion Date :
    Dec 1, 2014

    Arms and Interventions

    Arm Intervention/Treatment
    Oral cancer

    Subjects who suffer from oral cancer. Subjects must: Should have a blood exam (20ml/each time) before the surgery and 3 months after the surgery. In the case the disease recurs after the surgery, subjects need to receive the surgery again and take another blood exam before the surgery and 3 months after the surgery. Before the surgery site staff must: Collect subjects' saliva once a day (in the morning before breakfast) for 3 consecutive days. Collect a 0.5x0.5Cm2 tissue sample of the tumor during the surgery.

    Outcome Measures

    Primary Outcome Measures

    1. microRNA-29b [3 years]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years to 80 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • Cancer of the oral cavity.
    Exclusion Criteria:

    • pregnant woman

    • refuse the surgery

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 National Taiwan University Hospital research Ethics Committee Taipei Taiwan 10048

    Sponsors and Collaborators

    • National Taiwan University Hospital

    Investigators

    • Principal Investigator: Shin-Jung Cheng, DDS, MS, PhD,

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    Responsible Party:
    National Taiwan University Hospital
    ClinicalTrials.gov Identifier:
    NCT02009852
    Other Study ID Numbers:
    • 201309076RIN
    First Posted:
    Dec 12, 2013
    Last Update Posted:
    Dec 12, 2013
    Last Verified:
    Dec 1, 2013
    Keywords provided by National Taiwan University Hospital
    microRNA-29b
    Oral squamous cell carcinoma
    migration
    prognosis
    Additional relevant MeSH terms:
    Carcinoma
    Carcinoma, Squamous Cell
    Mouth Neoplasms
    Squamous Cell Carcinoma of Head and Neck

    Study Results

    No Results Posted as of Dec 12, 2013