Oral Manifestations of Human Immunodeficiency Virus Infection in High Risk Groups

Sponsor

National Institute of Dental and Craniofacial Research (NIDCR) (NIH)

Overall Status

Completed

CT.gov ID

NCT00004781

Collaborator

Columbia University (Other)

250

Enrollment

Study Details

Study Description

Brief Summary

OBJECTIVES: I. Evaluate the development of oral manifestations of human immunodeficiency virus infection in relationship to the onset of immunologic alterations and systemic symptoms in different risk groups: gay/bisexual men, male intravenous drug users, and female intravenous drug users.

Evaluate the immune and inflammatory response to periodontal and other microbial pathogens.
Evaluate the bacterial species infecting the oral cavity in patients in these risk groups.

Condition or Disease	Intervention/Treatment	Phase
HIV Infections Candidiasis, Oral

Detailed Description

PROTOCOL OUTLINE:

Patients undergo a periodontal assessment every 6 months until medically unable to continue. The oral/dental exam includes saliva and gingival crevicular fluid analysis and, as indicated, oral photographs.

Study Design

Study Type:

Observational

Study Start Date :

Sep 1, 1989

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

0 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics-- Human immunodeficiency virus infection (HIV) seropositive or seronegative At risk for HIV, i.e.: Gay/bisexual men Male intravenous drug users Female intravenous drug users No acquired immunodeficiency syndrome Currently enrolled in Columbia Presbyterian Medical Center protocol "The Natural History and Progression of HIV Infection"