Effect of Intravenous Lidocaine on Serum miRNA-135a in Patients Undergoing Non-cardiac Surgery
Study Details
Study Description
Brief Summary
The purpose of this study is to investigate the effects of intravenous lidocaine on serum miRNA-135a and its downstream proteins Rock2 and Add1 in elderly patients undergoing non-cardiac under general anesthesia.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Detailed Description
Postoperative cognitive dysfunction (POCD) is a major complication following surgeries and anesthesia, especially in elderly individuals. Lidocaine, an inexpensive, widely available, and relatively safe compound, is a local anesthetic that readily crosses the blood-brain barrier. Intravenous lidocaine can reduce the incidence of POCD. However, the mechanism is still unclear.
Rock2 and Add1, which are regulated by miRNA-135a, play a key role in learning, memory, and cognition.
The objective of this study is to investigate the efficacy of intravenous lidocaine on the incidence of early POCD, and the levels of Rock2, Add1, and miRNA-135a in elderly patients undergoing non-cardiac under general anesthesia.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: Lidocaine Intravenous bolus of 1.5 mg/kg of lidocaine followed by a continuous infusion of 3.0 mg/kg for the first hour, 1.5 mg/kg for the second hour, 0.7 mg/kg until the end of the surgery. |
Drug: Lidocaine
Intravenous bolus of 1.5 mg/kg of lidocaine followed by a continuous infusion of 3.0 mg/kg for the frst hour, 1.5 mg/kg for the second hour, 0.7 mg/kg until the end of the surgery.
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Placebo Comparator: Normal saline Normal saline administered as a bolus and an infusion with identical volume and rate changes as the treatment group. |
Drug: Normal saline
Patients are received equal volumes of saline intravenously until the end of the surgery
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Outcome Measures
Primary Outcome Measures
- Changes from Baseline miRNA-135A at the end of surgery immediately and 1, 3days after surgery [at preoperation, at the end of surgery immediately, 1day and 3day after surgery]
Venous blood was extracted, and the serum miRNA-135a level of patients were detected by PCR and ELISA before surgery, at the end of surgery, 1day and 3day after surgery
- Changes from Baseline Rock2 at the end of surgery immediately and 1, 3days after surgery [at preoperation, at the end of surgery immediately, 1day and 3day after surgery]
Venous blood was extracted, and the serum Rock2 level of patients were detected by PCR and ELISA before surgery, at the end of surgery, 1day and 3day after surgery
- Changes from Baseline Add1 at the end of surgery immediately and 1, 3days after surgery [at preoperation, at the end of surgery immediately, 1day and 3day after surgery]
Venous blood was extracted, and the serum Add1 level of patients were detected by PCR and ELISA before surgery, at the end of surgery, 1day and 3day after surgery
Secondary Outcome Measures
- Changes from Baseline mini-mental state examination (MMSE) at the end of surgery immediately and 1, 3days after surgery [at preoperation,1day and 3day after surgery]
MMSE was performed
Other Outcome Measures
- Postoperative cognitive dysfunction (POCD) [at preoperation,1day and 3day after surgery]
the incidence of POCD
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patients undergoing elective non-cardiac surgery under general anesthesia
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ASA physical status II-III
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Aged ≥65 years
Exclusion Criteria:
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Serious heart, lung, liver and kidney diseases
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Central nervous system injury
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Mental illness and drug dependence
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On regular use of analgesic/sedative/antidepressant
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Unable to cooperate
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Allergy to lidocaine
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MMSE < 23 points
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- General Hospital of Ningxia Medical University
Investigators
- Principal Investigator: Li Zhao, General Hospital of Ningxia Medical University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Li-Zhao