Orofacial Pain in Multiple Sclerosis
Study Details
Study Description
Brief Summary
Although the orofacial pain is not typical symptom of multiple sclerosis, more than 50% of the patients experience some kind of pain. Acute pain usually in form of trigeminal neuralgia, that occurred in 2-3% of patients with multiple sclerosis. Chronic pain occurred in 40-50% of patients and most common forms are headache. Aim of this study is to investigate prevalence and evaluate the form of orofacial pain in patients with multiple sclerosis treated in General hospital Varaždin in period from 01.01. 2017. to 31.12.2022. Results of this investigation will determine better understanding orofacial pain , treatment and impact on everyday life.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Multiple sclerosis is a chronic autoimmune disease with an unknown mechanism of origin. Although pain is not a typical symptom of multiple sclerosis, it occurs in more than 50% of patients and has significant impact on the quality of life of patients. Pain syndromes that patients with multiple sclerosis initially have characteristics of somatic and nociceptive pain, and later neuropathic, including trigeminal neuralgia, headaches, Lhermitte's syndrome.
Pain is also often associated with anxiety and depression, which occurs in almost one third of patients.
Pain therapy in these patients is a challenge for many doctors involved in the treatment. Many patients do not have adequate pain therapy due to the disproportion between the fear of interaction with other drugs and side effects, and on the other hand the treatment of basic diseases with the aim of controlling the immune response.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Multiple sclerosis group Multiple sclerosis patients registered in Varazdin General Hospital from 1 January 2017 - 31 December 2022 |
Diagnostic Test: Diagnosis of pain
Pain will be investigated - type, origin, level
|
Outcome Measures
Primary Outcome Measures
- The frequency of orofacial pain in patients with multiple sclerosis [3 months]
To investigate that, hospital records will be reviewed. Additionally, all of the patients will be approached with the questionnaire investigating the frequency of orofacial pain (expressed in number and proportion of all patients)
- The location of orofacial pain in patients with multiple sclerosis [3 months]
To investigate that, hospital records will be reviewed. Additionally, all of the patients will be approached with the questionnaire investigating the loacation of orofacial pain
- The duration of orofacial pain in patients with multiple sclerosis [3 months]
To investigate that, hospital records will be reviewed. Additionally, all of the patients will be approached with the questionnaire investigating the duration of orofacial pain (in months)
Secondary Outcome Measures
- MS therapy's influence to pain [3 months]
To investigate connection between orofacial pain and multiple sclerosis therapy
- MS orofacial pain and the duration of the disease [3 months]
To investigate the connection between orofacial pain and the duration of the disease
- Pain and patients' characteristics [3 months]
To investigate the pain characteristics in relation to age, sex, form of the disease
- Other chronic diseases and orofacial pain [3 months]
To investigate the influence of other chronic diseases on orofacial pain in patients with multiple sclerosis
- Pain and daily functioning [3 months]
To investigate the impact of pain on the daily functioning of patients with multiple sclerosis
Eligibility Criteria
Criteria
Inclusion Criteria:
-
multiple scerosis
-
age 18-85 years
Exclusion Criteria:
- records with missing data
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Varazdin General Hospital | Varaždin | Croatia | 42000 |
Sponsors and Collaborators
- Varazdin General Hospital
Investigators
- Principal Investigator: Monika Kocman Panic, MD, Varazdin General Hospital, Varazdin, Croatia
Study Documents (Full-Text)
None provided.More Information
Publications
- Danesh-Sani SA, Rahimdoost A, Soltani M, Ghiyasi M, Haghdoost N, Sabzali-Zanjankhah S. Clinical assessment of orofacial manifestations in 500 patients with multiple sclerosis. J Oral Maxillofac Surg. 2013 Feb;71(2):290-4. doi: 10.1016/j.joms.2012.05.008. Epub 2012 Jun 27.
- Di Stefano G, Maarbjerg S, Truini A. Trigeminal neuralgia secondary to multiple sclerosis: from the clinical picture to the treatment options. J Headache Pain. 2019 Feb 19;20(1):20. doi: 10.1186/s10194-019-0969-0.
- Fallata A, Salter A, Tyry T, Cutter GR, Marrie RA. Trigeminal Neuralgia Commonly Precedes the Diagnosis of Multiple Sclerosis. Int J MS Care. 2017 Sep-Oct;19(5):240-246. doi: 10.7224/1537-2073.2016-065.
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- Hirsh AT, Turner AP, Ehde DM, Haselkorn JK. Prevalence and impact of pain in multiple sclerosis: physical and psychologic contributors. Arch Phys Med Rehabil. 2009 Apr;90(4):646-51. doi: 10.1016/j.apmr.2008.10.019.
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- Solaro C, Brichetto G, Amato MP, Cocco E, Colombo B, D'Aleo G, Gasperini C, Ghezzi A, Martinelli V, Milanese C, Patti F, Trojano M, Verdun E, Mancardi GL; PaIMS Study Group. The prevalence of pain in multiple sclerosis: a multicenter cross-sectional study. Neurology. 2004 Sep 14;63(5):919-21. doi: 10.1212/01.wnl.0000137047.85868.d6.
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