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The Different Analgesic Potency of Volatile Anesthetics at Equi-MAC

Sponsor
Kangbuk Samsung Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT02609802
Collaborator
(none)
77
Enrollment
1
Location
2
Arms
8.9
Duration (Months)
8.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of this clinical trial is to evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth index.

Condition or Disease Intervention/Treatment Phase
Phase 3

Detailed Description

Volatile anesthetics vary in their relative hypnotic potencies. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetics produced different EEG-derived indices such as bispectral index. However, there was no controlled study that demonstrates the difference of analgesic potency. The aim of this clinical trial is to evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth index.

Study Design

Study Type:
Interventional
Actual Enrollment :
77 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose:
Prevention
Official Title:
The Different Analgesic Potency of Sevoflurane and Desflurane at Equi-minimum Alveolar Concentration
Study Start Date :
Nov 1, 2015
Actual Primary Completion Date :
Jul 28, 2016
Actual Study Completion Date :
Jul 28, 2016

Arms and Interventions

Arm Intervention/Treatment
Experimental: Sevoflurane

Anesthesia was maintained with sevoflurane.

Drug: Sevoflurane
Anesthesia was maintained with sevoflurane in patients undergoing arthroscopic shoulder surgery under general anesthesia and interscalene brachial plexus block.
Other Names:
  • SEVO

    		•
    Experimental: Desflurane

    Anesthesia was maintained with desflurane.

    Drug: Desflurane
    Anesthesia was maintained with desflurane in patients undergoing arthroscopic shoulder surgery under general anesthesia and interscalene brachial plexus block.
    Other Names:
  • DES

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Analgesic potency of volatile anesthetics [the first 60 min of maintaining a steady state 1 MAC of volatile agents]

      The analgesic potency was evaluated by surgical pleth index value

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    19 Years to 65 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • patients undergoing arthroscopic shoulder surgery

    • patients with american society of anesthesiologist physical status I, II

    • patients aged 19-65 years

    • patients obtaining written informed consent

    Exclusion Criteria:

    • patients with a history of any psychiatric or neurological disease

    • patients who had received any medication affecting the central nervous system

    • patients who had received medication affecting the sympathetic or parasympathetic nervous systems

    • patients who have not received interscalene approach brachial plexus block (refusal or failure)

    • pregnant women

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Kangbuk Samsung Hospital Seoul Korea, Republic of 03181

    Sponsors and Collaborators

    • Kangbuk Samsung Hospital

    Investigators

    • Principal Investigator: Kyoungho Ryu, M.D., Kangbuk Samsung Hospital

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Kyoungho Ryu, Clinical assistant professor, Kangbuk Samsung Hospital
    ClinicalTrials.gov Identifier:
    NCT02609802
    Other Study ID Numbers:
    • 2015-09-028
    First Posted:
    Nov 20, 2015
    Last Update Posted:
    Nov 8, 2017
    Last Verified:
    Nov 1, 2017
    Individual Participant Data (IPD) Sharing Statement:
    Undecided
    Plan to Share IPD:
    Undecided
    Additional relevant MeSH terms:
    Musculoskeletal Diseases
    Sevoflurane
    Desflurane

    Study Results

    No Results Posted as of Nov 8, 2017