SPECT-CT vs MRI for the Diagnosis of Osteoarthritis in the Foot and Ankle
Study Details
Study Description
Brief Summary
The diagnose of symptomatic osteoarthritis in the ankle, mid- and hind foot remains challenging. There is no gold standard for the work-up and various hospitals use different protocols. Current literature shows a promising role for SPECT-CT imaging in ankle, hind- and midfoot OA. In a previous study investigating the role of SPECT-CT in a reproducible group we have observed a change in diagnosis in 53% when SPECT-CT data was added to the data of conventional workup alone. In 26% of patients addition of SPECT-CT data resulted in change of the original treatment plan. To our knowledge no prospective studies are available on this subject for both SPECT-CT and MRI. In our clinic both SPECT-CT and MRI are used in the work-up for patients with ankle, hind- and midfoot pain. Although we experience good result with SPECT-CT, MRI might be able to detect symptomatic OA as well. Moreover MRI provide more information about soft tissue and is less harmful for the patient in comparison to SPECT-CT. The aim of this study is to determine the diagnostic performance of SPECT-CT and MRI when used routinely in patients with symptomatic OA of the ankle, hind- and midfoot.
| Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Objective: The objective is to determine diagnostic performance of SPECT-CT and MRI when used routinely in patients with symptomatic OA of the ankle, hind- and midfoot.
Study design: Prospective cohort study.
Study population: All patients ≥18years old, referred to the Martini Hospital Groningen department of Orthopedic surgery with suspected symptomatic osteoarthritis of the foot and ankle and rest pain of NRS ≥4.
Main study parameters/endpoints: Main parameters will be the diagnostic performance (a.o. sensitivity and specificity, positive and negative predictive value)of SPECT-CT and MRI.
The standard work up consist of questionnaires, detailed physical examination, conventional radiographic, MRI, SPECT-CT imaging and ultrasound guided injections. There are no additional risks for participating in this study compared to current standardised hospital workup.
Study Design
Outcome Measures
Primary Outcome Measures
- Diagnostic accuracy of SPECT/CT and MRI [1 year]
Primary objective is to determine overall diagnostic performance (in terms of sensitivity + specificity, positive and negative predictive values, positive and negative likelihood ratios, and diagnostic odds ratio) of SPECT-CT and MRI for diagnosing symptomatic OA in the ankle, hind- and midfoot.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Suspected symptomatic ankle, hind- or midfoot OA
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Informed consent
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Age ≥ 18 years
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Average NRS ≥4 in rest over the past week.
Exclusion Criteria:
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Contraindication for surgery
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Contraindication for SPECT-CT or MRI
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Contraindication for intra-articular injections
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Isolated forefoot pathology
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Fracture, ligamentous or tendon injury of the ankle, hind- and/or midfoot trauma within one year before presentation
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History of neurological disease
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History of foot and/or ankle surgery (affected side)
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Inability to read and understand the written information
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Martini Hospital | Groningen | Netherlands | 9728 NT |
Sponsors and Collaborators
- Martini Hospital Groningen
Investigators
- Principal Investigator: Tom van Raaij, MD/PhD, Martini Ziekenhuis
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- ProSPECT study