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BMRR3: Effects Of Unilateral Vibration On Contralateral Forearm Muscle Activity

Sponsor
Vakif Gureba Training and Research Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT01097122
Collaborator
(none)
90
Enrollment
1
Location
1
Arm
4
Duration (Months)
22.5
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study hypothesize that radius subjecting to mechanical loading may affect excitability of alpha motor neuron innervating muscle, based on its bone mineral density or bone mineral content.

A total of 80 voluntaries are planned to include in this study. Vibration will be applied the right forearm. Muscle electrical activity will be measured on ipsilateral and contralateral flexor carpi radialis (FCR) muscle at rest as EMGrms by surface electromyography (EMG). The rest-EMGrms will be measured at before and during vibration. An increase in muscle electrical activity at rest indicates an increase in motor neuron pool activation. The right distal radius bone mineral content (BMC) and density will be measured by dual energy X-ray absorptiometry (DXA).

The right radius bone mineral density (BMD) and BMC will be evaluated by bone densitometer (GE-LUNAR DPX PRO).

Motor unit potentials will be measured by electromyography at left flexor carpi radialis. Neurotrac ETS device will be used.

Condition or Disease Intervention/Treatment Phase
  • Procedure: Forearm vibration
 N/A

Detailed Description

A functional cooperation exists between bones and skeletal muscles. Bones work together with muscles as a simple mechanical lever system to produce body movement. One of the important functions of bones is to exert resistance against gravity in order to carry the body. In order to carry out their mechanical functions, bones need to have considerable resistance to deformation under load. It is well-known that muscle activity (i.e., exercises) improves the resistance of bone to mechanical loading, and that it is also important for treating and preventing osteoporosis. Resistance and impact training have been shown to induce bone formation and/or prevent bone resorption. Skeletal muscles have positive effects on bone structure and function. Can bones have an effect on muscle activity? There is only one study about the effect of bones on muscles. In this study, it was shown that bones may affect muscle strength gain in healthy young adult males.

Vibration has a strong osteogenic effect. Vibration-induced bone formation is neuronally regulated. Vibration can also effectively enhance muscle strength and power. Previous studies have shown that vibration increases muscle electromyographic (EMG) activity. But, it has not been reported whether bone has an effect on the increase in muscle EMG activity caused by vibration or not. The aim of this study was to determine whether radius bone exposed to cyclic mechanical loading affects muscle electrical activity of contralateral untrained m. flexor carpi radialis in healthy adult volunteers.

Study Design

Study Type:
Interventional
Actual Enrollment :
90 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Masking:
Double (Participant, Outcomes Assessor)
Primary Purpose:
Basic Science
Official Title:
Effects Of Unilateral Forearm Vibration On Electrical Activity Of Untrained Contralateral Forearm Muscle
Study Start Date :
Mar 1, 2010
Actual Primary Completion Date :
Jun 1, 2010
Actual Study Completion Date :
Jul 1, 2010

Arms and Interventions

Arm Intervention/Treatment
Experimental: Healthy young adult subjects

Forearm vibration will be applied in healthy young adult subjects

Procedure: Forearm vibration
Mechanical loading with forearm vibration will be applied right radius in all groups
Other Names:
  • Cyclic mechanical loading

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Changes in rest muscle electrical activity in the contralateral untrained flexor carpi radialis during the right forearm vibration [2 or 3 weeks]

      Rest muscle electrical activity changes will be examined in the contralateral untrained flexor carpi radialis during the right forearm vibration

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years to 50 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • Healthy subjects

    • Right handed

    • Young adult women and men

    Exclusion Criteria:

    • secondary osteoporosis

    • neuropathy (central or peripheral)

    • myopathy

    • systemic diseases (arthritis, endocrine-metabolic diseases, bone diseases)

    • professional sportswoman/sportsman

    • subjects doing regular sports activities

    • tendinopathy

    • amputee, endoprosthesis, metal implants

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Vakif Gureba Training & Research Hospital İstanbul Turkey 34000

    Sponsors and Collaborators

    • Vakif Gureba Training and Research Hospital

    Investigators

    • Study Chair: ILHAN KARACAN, MD, Vakif Gureba Training & Research Hospital

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    ILHAN KARACAN, ILHAN KARACAN, Vakif Gureba Training and Research Hospital
    ClinicalTrials.gov Identifier:
    NCT01097122
    Other Study ID Numbers:
    • VGEAH FTR-3
    First Posted:
    Apr 1, 2010
    Last Update Posted:
    Feb 27, 2012
    Last Verified:
    Feb 1, 2012
    Keywords provided by ILHAN KARACAN, ILHAN KARACAN, Vakif Gureba Training and Research Hospital
    bone
    motor neuron excitability
    forearm vibration
    mechanical loading
    muscle electrical activity
    Additional relevant MeSH terms:
    Osteoporosis

    Study Results

    No Results Posted as of Feb 27, 2012