Determination of Adipocyte Parameters in Iliac Crest Biopsies From Post Menopausal Women

• Sponsor: Mayo Clinic (Other)
• Overall Status: Completed
• CT.gov ID: NCT00443716
• Collaborator: (none)
• Enrollment: 60
• Location: 1
• Duration (Months): 48
• Patients Per Site Per Month: 1.3

Study Details

Study Description

Brief Summary

To evaluate the effect of estrogen treatment on adipocytic and osteoblastic parameters by histomorphometrically measuring adipocyte volume (AV/TV) and adipocyte numbers in goldner's stained iliac crest bone biopsy specimens collected from subjects recruited in the study (IRB number 21B85). The adipocytic parameters will be then correlated with osteoblastic parameters obtained previously during the course of the initai study involving the effect of transdermal estrogen on bone turnover in postmenopausal osteoporotic women.

Condition or Disease	Intervention/Treatment	Phase
Osteoporosis; Postmenopausal	Drug: estrogen	N/A

Study Design

• Study Type: Interventional
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: Determination of Adipocyte Parameters in Iliac Crest Biopsies From Post Menopausal Women
• Study Start Date: Apr 1, 1985
• Actual Primary Completion Date: Apr 1, 1989
• Actual Study Completion Date: Apr 1, 1989

Outcome Measures

Primary Outcome Measures

1. efficacy of estraderm treatment on osteoporotic women []

Eligibility Criteria

Criteria

• Ages Eligible for Study: 30 Years and Older
• Sexes Eligible for Study: Female
• Accepts Healthy Volunteers: Yes

Post-menopausal osteoporotic women

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Mayo Clinic	Rochester	Minnesota	United States	55905

Sponsors and Collaborators

• Mayo Clinic

Investigators

• Principal Investigator: B. Lawrence Riggs, M.D., Mayo Clinic

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT00443716
• Other Study ID Numbers: 05-004111; 21b85
• First Posted: Mar 6, 2007
• Last Update Posted: Jan 15, 2010
• Last Verified: Jan 1, 2010

• Additional relevant MeSH terms: Osteoporosis; Estrogens

Study Results

No Results Posted as of Jan 15, 2010