Otoacoustic Emission Suppression Study
Study Details
Study Description
Brief Summary
The focus of this project is on a physiologic auditory response called the Medial Olivocochlear Reflex (MOCR) that assesses peripheral neural function. While neural hearing loss is a significant auditory disorder in patients of all ages, more than 50% of newborn infants are screened with a technology that is not sensitive to abnormalities in neural function. The development of a time-efficient and sensitive test system to assess the MOCR will provide significant benefit to infants and patients of all ages with neural deficits who would otherwise go undetected.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
The objective of this study is to develop an optimized hearing testing method using otoacoustic emissions, that can be used to efficiently assess peripheral neural function (including retrocochlear disorders) using the medial olivocochlear reflex (MOCR). Measuring neural function via the MOCR. This reflex has been shown to be abnormal in patients with neural disorders. The focus of this project will be the development of a screening method that incorporates OAE screening and measurement of the MOCR in the same test procedure. The target population in the proposed research is infants, particularly those in environments where auditory brainstem response (ABR) screening is not performed routinely. Addition of the MOCR to screening where ABR is not performed will address the shortcoming of OAE screening which misses neural forms of hearing loss.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Newborns Otoacoustic Emissions to be measured with and without suppression noise |
Diagnostic Test: Measurement of Otoacoustic Emissions with and without suppression noise
Otoacoustic emissions will be recorded using an ear probe with and without a suppression noise.
|
| Newborns failing initial hearing screening test Otoacoustic Emissions to be measured with and without suppression noise |
Diagnostic Test: Measurement of Otoacoustic Emissions with and without suppression noise
Otoacoustic emissions will be recorded using an ear probe with and without a suppression noise.
|
| Adults with normal hearing Otoacoustic Emissions to be measured with and without suppression noise |
Diagnostic Test: Measurement of Otoacoustic Emissions with and without suppression noise
Otoacoustic emissions will be recorded using an ear probe with and without a suppression noise.
|
| Adults with hearing loss Otoacoustic Emissions to be measured with and without suppression noise |
Diagnostic Test: Measurement of Otoacoustic Emissions with and without suppression noise
Otoacoustic emissions will be recorded using an ear probe with and without a suppression noise.
|
Outcome Measures
Primary Outcome Measures
- Otoacoustic Suppression Measure [Immediately after the intervention]
The amplitude of the otoacoustic emission response will be measured when recorded with and without a suppression noise.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Normal middle-ear function
-
Present TEOAEs.
Exclusion Criteria:
- Atresia or other external ear abnormalities not allowing recording of OAEs
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Vanderbilt University Medical School | Nashville | Tennessee | United States | 37232 |
Sponsors and Collaborators
- Intelligent Hearing Systems
- National Institute on Deafness and Other Communication Disorders (NIDCD)
- Vanderbilt University
Investigators
- Study Director: Linda J Hood, PHD, Vanderbilt University Medical School
- Principal Investigator: Rafael E Delgado, PHD, Intelligent Hearing Systems Corp
Study Documents (Full-Text)
None provided.More Information
Publications
- Hood LJ, Berlin CI, Bordelon J, Rose K. Patients with auditory neuropathy/dys-synchrony lack efferent suppression of transient evoked otoacoustic emissions. J Am Acad Audiol. 2003 Aug;14(6):302-13.
- Hood LJ, Berlin CI, Hurley A, Cecola RP, Bell B. Contralateral suppression of transient-evoked otoacoustic emissions in humans: intensity effects. Hear Res. 1996 Nov 1;101(1-2):113-8.
- James AL. The assessment of olivocochlear function in neonates with real-time distortion product otoacoustic emissions. Laryngoscope. 2011 Jan;121(1):202-13. doi: 10.1002/lary.21078.
- MOCR