Analysis of Outcomes and Adverse Events of Patients Undergoing Radiation Therapy
Study Details
Study Description
Brief Summary
Analysis of outcomes and adverse events of patients undergoing radiation therapy. Quality control using data base of patient records 2000-2025
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
What are the findings of the systematic recording and analysis of the outcomes and adverse events of radiotherapy, and how do these findings improve radiotherapy for future patients?
The goals of the systematic collection and analysis of patient-related personal data include:
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Quality assurance and showing where the quality can be improved
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Recording the outcomes and side effect profile of radiotherapy and adapting to prevent serious side effects in the future
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Presentation and publication as part of the clinical research program at the Institute for Radio-Oncology of the Winterthur Cantonal Hospital
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Data Base of Patient Records 2000-2025 Analysis of outcomes and adverse events |
Radiation: Radiotherapy
Outcomes and adverse events using radiation therapy
|
Outcome Measures
Primary Outcome Measures
- Overall survival (OS) and progression free survival (PFS) analysis after radiation therapy [25 years]
Calculation of Overall survival (OS) and progression free survival (PFS). Time-to-event endpoints are summarized as the median and corresponding 95% confidence interval using Kaplan-Meier method
- Analysis of risk factors influencing outcome after radiation therapy [25 years]
Calculation of log-rank tests. If possible, hazard ratios are calculated via Cox regression. Competing risk analysis is conducted as supportive analysis
Secondary Outcome Measures
- Number of patients with acute and late adverse events after radiation therapy [25 years]
Predefined toxicity events are described by type, grade, frequency, and percentage across all time points. Fisher's exact tests are used for comparison (base line and defined time points). Quality of life symptom and function scales are used. Two-tailed tests with a significance level of 0.05 are used for all analyses. Adjustments for multiple testing may be used. Some of the analyses are exploratory and hypothesis generating
Eligibility Criteria
Criteria
Inclusion Criteria:
- Patients who are being treated with radiotherapy at the Department of Radiation Oncology at the Winterthur Cantonal Hospital
Exclusion Criteria:
- No radiotherapy at the Department of Radiation Oncology at the Winterthur Cantonal Hospital <16 years,> 105 years
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Kantonsspital Winterthur | Winterthur | Zurich | Switzerland | 8401 |
Sponsors and Collaborators
- Daniel Zwahlen
Investigators
- Principal Investigator: Daniel Zwahlen, MD, MBA, Kantonsspital Winterthur KSW
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- BASEC-Nr. 2020-02112