RIGHT-MARE: Outcomes After PCI of the Aneurysmatic Right Coronary Artery
Study Details
Study Description
Brief Summary
This study aims to evaluate procedural and clinical outcomes of ACS patients with aneurysmatic culprit RCA.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
The investigators sought differences in procedural (slow-flow, no-reflow, distal embolisation, TIMI final flow etc.) and in immediate and long-term clinical outcomes between several subgroups such as index vs staged PCI, premedication vs none, use of IIb/IIIa inhibitors vs none, BMS vs DES, ultrathin DES vs thick DES, durable polymer vs bioresorbable or free polymer etc.
The investigators also want to investigate the efficacy of different technical manoeuvres involved in resolving high thrombotic burden before stent deployment, such as thrombus aspiration, dilatation, intracoronary infusion of adenosine or thrombolytic agents, direct stenting etc.). Long-term follow-up includes target vessel failure (Cardiac Death, target vessel MI, clinically-driven target vessel revascularisation), define or probable stent thrombosis, target vessel revascularisation for ACS, clinically driven target vessel revascularisation and intrastent restenosis.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Index PCI Patients with an aneurysmatic right coronary artery undergoing index PCI in the acute setting. |
Procedure: Percutaneous Coronary Intervention
Treatment of coronary stenoses with a drug-eluting stent or balloon
|
| Staged PCI Patients with an aneurysmatic right coronary artery undergoing staged PCI in the acute setting. |
Procedure: Percutaneous Coronary Intervention
Treatment of coronary stenoses with a drug-eluting stent or balloon
|
Outcome Measures
Primary Outcome Measures
- Technical success [Procedural (from the start to the end of the procedure)]
Defined as final TIMI flow > 3 (TIMI 0: absence of any integrate flow beyond the coronary occlusion; TIMI 1: faint antegrade flow beyond the coronary occlusion with incomplete filling of the distal coronary bed; TIMI 2: delayed flow beyond the coronary occlusion with complete filling of the distal coronary bed; TIMI 3: normal flow with complete filling of the distal coronary bed)
Secondary Outcome Measures
- Target Lesion Failure [12 moths]
Combination of cardiac death, target vessel MI and clinically target lesion revascularization
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients with ACS of the aneurysmatic or ectasic RCA
-
Patient with at least 6 months clinical or angiographic follow-up
-
Patients with accurate procedural and clinical records (particularly use of drugs before, during and after procedure, according to RCA PCI procedure (index or staged).
Exclusion Criteria:
-
Elective aneurysmatic or ectasic RCA PCI
-
Patient with lack of accurate procedural and clinical data
-
Patient with lack of clinical or angiographic follow up
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Ospedale Papa Giovanni XXIII | Bergamo | Italy | ||
| 2 | Azienda Ospedaliera Brotzu | Cagliari | Italy | 09047 | |
| 3 | Policlinico Universitario G.Rodolico | Catania | Italy | 95123 | |
| 4 | Azienda Ospedaliera Universitaria Gaetano Martino | Messina | Italy | 98124 | |
| 5 | Ospedale Auxologico San Luca | Milan | Italy | ||
| 6 | Interventional Unit, San Luigi Gonzaga University Hospital, Orbassano, and Rivoli Hospital, Turin, Italy | Turin | Italy | 10100 | |
| 7 | Ospedale Universitario Marqués de Valdecilla | Santander | Satander | Spain | 39008 |
| 8 | Hospital Clinico San Carlos | Madrid | Spain |
Sponsors and Collaborators
- San Luigi Gonzaga Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 001-2022