Antioxidants vs. Ovarian Bio-stimulation Therapy to Rescue the Ovarian Reserve
Study Details
Study Description
Brief Summary
Two group of patients were selected. Group 1 represents 46 patients that received ovarian-biostimulation monthly for three months. Group 2 represents 32 patients that received antioxidant therapy daily for 3 months. Results are noted and analysed.
Both groups represent patients with procedures already ongoing, and with diagnosed poor or depleted ovarian reserve.
The analysis has been made to compare the efficacy of both procedures.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
The bioestimulation group received a blood rich platelet therapy monthly for three months, with a technique developed by the laboratory. The second group of antioxidants received a combination of antioxidants monthly for three months. Both groups were compared to assess the results in terms of ovarian response (number of astral follicles, AMH levels, FSH, LH), and egg quality, embryo development, implantation rate, and successful pregnancy with healthy live birth.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: ovarian bio-stimulation Intervention: ovarian bio-stimulation: blood rich plasma platelets |
Procedure: blood rich plasma platelets
Injection of blood rich platelet into the ovaries.
Dietary Supplement: Antioxidant therapy
Antioxidants:
Q10, DHEA, Vitamina E, Vitamin C, Omega 3
|
| Active Comparator: Antioxidant therapy Intervention: antioxidants: Q10, DHEA, Vitamin E, Vitamin C, omega 3 |
Procedure: blood rich plasma platelets
Injection of blood rich platelet into the ovaries.
Dietary Supplement: Antioxidant therapy
Antioxidants:
Q10, DHEA, Vitamina E, Vitamin C, Omega 3
|
Outcome Measures
Primary Outcome Measures
- variation of hormones FSH and LH directly involved with ovarian reserve [18 months]
Both groups are compared after bio-stimulation and antioxidant therapy is performed to access any possible changes with FSH-LH post-treatment.
- variation of AMH directly involved with ovarian reserve in both groups [18 months]
Both groups are compared after bio-stimulation and antioxidant therapy is performed to access any possible changes with AMH values.
- variation in recruitment of antral follicles in both groups [18 months]
Both groups are compared after bio-stimulation and antioxidant therapy is performed to access any possible changes with the number of astral follicles available.
Secondary Outcome Measures
- Number of good quality eggs obtained in both groups after IVF [18 months]
Egg quality is evaluated in both group of women undergoing IVF after bio-stimulation or antioxidant therapy are performed
- Number and quality of fertilised eggs obtained in both groups after IVF [18 months]
the number and quality of fertilised eggs is evaluated in both groups of women undergoing IVF after bio-stimulation or antioxidant therapy is performed.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age between 38 and 46 years
-
FSH> 12 mIU
-
Estradiol > 100 pg/ml
-
AMH < 0.8 ng/mL
Exclusion Criteria:
-
Pelvic inflammatory syndrome
-
vaginal pathologies
-
known history of hyperandrogenism
-
diagnosed platelet disorders as adhesion
-
aggregation
-
disorder of thromboxane synthesis.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Fertiaguerrevere Fertility | Caracas | Disfrito Federal | Venezuela | 1018 |
Sponsors and Collaborators
- Lucy Coleman
Investigators
- Principal Investigator: Carmen Navarro, MD, Medical staff
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- J298384255