The Effects of Overfeeding on Obesity-Prone (OP) and Obesity-Resistant (OR) Women

Sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (NIH)

Overall Status

Completed

CT.gov ID

NCT00072917

Collaborator

(none)

100

Enrollment

Location

Duration (Months)

1.8

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This is a longitudinal cohort study of how the responses to a 3 day period of controlled overfeeding relate to subsequent weight gain. We hypothesize that thin individuals are resistant to weight gain because they respond to periods of overfeeding by increasing fat oxidation, reducing food intake, and increasing physical activity relative to those who gain weight over time.

Condition or Disease	Intervention/Treatment	Phase
Obesity Thinness Weight Gain

Study Design

Study Type:

Observational

Anticipated Enrollment :

100 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

The Effects of Overfeeding on Obesity-Prone (OP) and Obesity-Resistant (OR) Women

Study Start Date :

Oct 1, 2003

Study Completion Date :

Jun 1, 2008

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

25 Years to 35 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Half of the subjects will be women, half will be men,
age 25-35,
a range of BMI's from 19-27, for the 'thin subjects' there should be no 1st degree relatives with a BMI>30.
Subjects should not engage in planned physical activity more than 3 hrs per week.
For the obesity prone group there should be at least 1 1st degree relative with a BMI>30.