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EXCEL: EXerCise wEight Loss

Sponsor
University of Glasgow (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT05702840
Collaborator
(none)
50
Enrollment
2
Arms
12
Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

The overall aim of this study is to investigate the effects of home-based resistance exercise programme on changes in body composition and strength during weight loss, in people living with obesity or overweight.

Condition or Disease Intervention/Treatment Phase
  • Behavioral: Resistance exercise training + weight loss group
  • Behavioral: Weight loss only group (WL)
 N/A

Study Design

Study Type:
Interventional
Anticipated Enrollment :
50 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Intervention Model Description:
Randomised controlled pilot trial with two groups, resistance exercise + weight loss group and weight loss only group.Randomised controlled pilot trial with two groups, resistance exercise + weight loss group and weight loss only group.
Masking:
Single (Outcomes Assessor)
Masking Description:
Members of the research team that perform measurements are blinded to group allocation.
Primary Purpose:
Basic Science
Official Title:
The Effects of a Home-based Resistance Training Programme on Body Composition and Muscle Function During Weight Loss in People With Overweight or Obesity: a Randomised Controlled Pilot Trial
Anticipated Study Start Date :
Feb 1, 2023
Anticipated Primary Completion Date :
Feb 1, 2024
Anticipated Study Completion Date :
Feb 1, 2024

Arms and Interventions

Arm Intervention/Treatment
Experimental: Resistance exercise training + weight loss group (RT+WL)

Participants (WL-RT) will be provided with a resistance exercise booklet containing instructions for exercises and links to demonstration videos. A demonstration and explanation of the exercises will be given at the beginning of the intervention, alongside a discussion of the principles of the programme such as starting level and progression. We will ask participants to perform the resistance exercises for 12-week period. Participants will be asked to perform exercises 3 times a week (3 sets reaching the RPE scale between 8 - 10 out of 10 (4-6 out of 10 in the first week)) for the intervention period. The exercises will include press-ups, band lateral raises, band seated low row, squat, lunge and calf raise.

Behavioral: Resistance exercise training + weight loss group
Doing resistance exercises as well as following the weight watchers weight loss programme for a 12-week period
Experimental: Weight loss only group (WL)

All participants (WL and WL-RT) will be provided with vouchers to access the weight watchers weight loss programme for a 12-week period. Weight Watchers is a commercially available programme and participants will set an initial goal to lose 5kg of body mass. If 5kg weight loss is achieved then the participant can chose further weight loss goals, as long as it would result in a body mass in the weight watchers healthy weight range (https://www.weightwatchers.com/uk/weight-loss/programme/tools/healthy-weight-chart).This plan works on the basis of an individualised points plan that can then be used by the participant to select foods/meals to consume throughout the day.

Behavioral: Weight loss only group (WL)
Only following the weight watchers weight loss programme for a 12-week period

Outcome Measures

Primary Outcome Measures

  1. Change in whole body lean mass [Change from baseline to 12 weeks]

    whole body lean mass measured via bio-electrical impedance

Secondary Outcome Measures

  1. Change in whole body fat mass [Change from baseline to 12 weeks]

    whole body fat mass measured via bio-electrical impedance

  2. Change in body mass [Change from baseline to 12 weeks]

    body mass measured on scales

  3. Change in vastus lateralis muscle thickness [Change from baseline to 12 weeks]

    Muscle thickness of the vastus lateralis muscle measured via ultrasound

  4. Change in knee extensor maximal isometric torque [Change from baseline to 12 weeks]

    Knee extensor maximal isometric torque measured during a maximal voluntary contraction

  5. Change in grip strength [Change from baseline to 12 weeks]

    Grip strength measured with a hand held dynamometer

  6. Change in functional physical abilities [Change from baseline to 12 weeks]

    A 30-second sit-to-stand test measured functional abilities

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 65 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

  • Obesity or overweight (BMI ≥ 25kg/m2).

  • Passing the Physical Activity Readiness Questionnaire (PAR-q+)

Exclusion Criteria:

  • Currently take part in more than 1.5 hours of structured exercise per week.

  • Having recently (<6 months) taken part in any resistance exercise training, taking any medications known to affect weight loss.

  • Actively engaged in a weight loss programme, having lost more than 2kg weight in the last 6 months.

  • Any other reason which would limit ability to perform the exercises and outcome measurements safely.

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

  • University of Glasgow

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

Responsible Party:
Stuart Gray, Professor, University of Glasgow
ClinicalTrials.gov Identifier:
NCT05702840
Other Study ID Numbers:
  • EXerCise wEight Loss Study
First Posted:
Jan 27, 2023
Last Update Posted:
Jan 27, 2023
Last Verified:
Jan 1, 2023
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:
Obesity
Overweight
Weight Loss

Study Results

No Results Posted as of Jan 27, 2023