Study on Whether Tart Cherry Juice Can Reduce Oxidative Stress and Inflammation

• Sponsor: Kronos Longevity Research Institute (Other)
• Overall Status: Completed
• CT.gov ID: NCT00847743
• Collaborator: Vanderbilt University (Other)
• Enrollment: 12
• Location: 1
• Duration (Months): 6
• Patients Per Site Per Month: 2

Study Details

Study Description

Brief Summary

Oxidative stress has been linked to many diseases associated with aging, including coronary heart disease and Alzheimer's disease. Antioxidants and special proteins in the body work together to help prevent damage by free radicals. Some studies have indicated that as people age, they are less able to fight off oxidative stress and have increased levels of inflammation.

Tart cherries are known to be rich in antioxidants and plant-nutrients. The product we are using in this study is an all-natural tart cherry juice, mixed with apple juice concentrate and containing no additives and no preservatives.

We hope to learn whether antioxidant supplementation, such as tart cherry juice, can measurably decrease oxidative damage and inflammation associated with aging.

Condition or Disease	Intervention/Treatment	Phase
Oxidative Stress; Antioxidant Capacity; Inflammation	Dietary Supplement: Tart Cherry Juice	N/A

Detailed Description

Objectives

The primary objective of this pilot study is to investigate whether tart cherry juice consumption can reduce oxidative stress in older adults as measured by attenuation of F2-isoprostane responses to a forearm ischemia-reperfusion, and a decrease in urinary excretion products of oxidative damage. The secondary objective is to examine whether age-sensitive markers of inflammation are reduced in response to the cherry juice consumption.

Study Design

• Study Type: Interventional
• Actual Enrollment: 12 participants
• Allocation: Randomized
• Intervention Model: Crossover Assignment
• Masking: Double (Participant, Investigator)
• Primary Purpose: Prevention
• Official Title: Effects of Tart Cherry Juice on Oxidative Stress and Inflammation in Older Men and Women
• Study Start Date: Oct 1, 2007
• Actual Primary Completion Date: Apr 1, 2008
• Actual Study Completion Date: Apr 1, 2008

Outcome Measures

Primary Outcome Measures

1. plasma F2-isoprostane response to a forearm ischemia-reperfusion challenge. []

Secondary Outcome Measures

1. Urinary markers of oxidative damage. []

Eligibility Criteria

Criteria

• Ages Eligible for Study: 55 Years to 80 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• men and women, ages 55-80y, in good health, with >8 years of education

• non-smoker

• able to give informed consent

Exclusion Criteria:

• use of anti-oxidant supplements, in excess of a standard multi-vitamins

• current hormone replacement therapy

• any history of significant chronic disease

• uncontrolled hypertension

• body mass index (BMI) > 30 kg/m2

• high physical activity level, as determined by questions on the screening questionnaire

• use of anti-inflammatory medication

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Kronos Longevity Research Institute	Phoenix	Arizona	United States	85016

Sponsors and Collaborators

• Kronos Longevity Research Institute
• Vanderbilt University

Investigators

• Principal Investigator: Tinna Traustadottir, Ph.D., Kronos Longevity Research Institute

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT00847743
• Other Study ID Numbers: KLRI-2007-03
• First Posted: Feb 19, 2009
• Last Update Posted: Feb 19, 2009
• Last Verified: Feb 1, 2009

• Keywords provided by , ,: oxidative stress; aging; ischemia-reperfusion
• Additional relevant MeSH terms: Inflammation

Study Results

No Results Posted as of Feb 19, 2009