Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

Sponsor

National Taiwan University Hospital (Other)

Overall Status

Unknown status

CT.gov ID

NCT00745888

Collaborator

(none)

200

Enrollment

Location

Study Details

Study Description

Brief Summary

In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. There are some questions on the oxidative stress of the critical illness. First, the investigators want to search out the effects of the past history, smoking, alcohol drinking, use of antioxidants, different diseases, and different duration of SIRS on the degree of oxidative stress. Second, besides total count of ROS, the investigators used new techniques to determine superoxide(O2●-), hydrogen peroxide (H2O2), and hypochlorous acid(HOCl). Furthermore, we want to investigate the correlation of the degree of different reactive oxygen species and the severity of SIRS or shock. Third, we try to investigate the correlation between the change of oxidative stress and the prognosis of the patients.

The investigators wish this study will help them to investigate the effect of oxidative stress on critical ill patients, to modulate the oxidative stress, to decrease the occurrence of SIRS, shock, and multiorgan failure, and to improve the long term outcome of patients.

Condition or Disease	Intervention/Treatment	Phase
Sepsis Shock	Other: Chemiluminescence Analyzer

Study Design

Study Type:

Observational

Anticipated Enrollment :

200 participants

Time Perspective:

Prospective

Official Title:

Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

Study Start Date :

May 1, 2007

Arms and Interventions

Arm	Intervention/Treatment
1 age > 18 y/o Patients admitted to surgical ICU	Other: Chemiluminescence Analyzer measure reactive oxygen species

Arm

Intervention/Treatment

age > 18 y/o Patients admitted to surgical ICU

Other: Chemiluminescence Analyzer

measure reactive oxygen species

Outcome Measures

Primary Outcome Measures

28-day Survival [28 days]

Secondary Outcome Measures

Days stay in ICU Days on ventilator SOFA score Complications [28 days]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Age > 18 y/o
Admitted to surgical ICU

Exclusion Criteria:

Patients with brain death

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	National Taiwan University Hospital	Taipei		Taiwan	100

Sponsors and Collaborators

National Taiwan University Hospital

Investigators

Principal Investigator: Yu-Chang Yeh, National Taiwan University Hospital

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

, ,

ClinicalTrials.gov Identifier:

NCT00745888

Other Study ID Numbers:

9561709132

First Posted:

Sep 3, 2008

Last Update Posted:

Sep 9, 2009

Last Verified:

Aug 1, 2009

Keywords provided by , ,

oxidative stress

intensive care

Postoperative intensive care

Study Results

No Results Posted as of Sep 9, 2009