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Evaluation of Oxidative Stress and Effect of Levothyroxine Treatment on Oxidative Stress in Hashimoto Disease

Sponsor
Vakif Gureba Training and Research Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT01102205
Collaborator
(none)
130
Enrollment
1
Location
6
Duration (Months)
21.6
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Oxidative stress leads to or accompanies with numerous disease. Oxidative balance in subclinical hypothyroid or euthyroid state in Hashimoto disease are not known. Effect of levothyroxine therapy on oxidative balance are also not known in hashimoto disease.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    oxidative stress markers will be measured initially(TAS,TOS,OSI,PARAOXONASE,ARYLESTERASA,PON1 PHENOTYPİNG,LİPİDPEROXİD).After 3 months therapy with levothyroxine measurements will be repeated except PON1 phenotyping.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    130 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Evaluation of Oxidative Stress and Effect of Levothyroxine Treatment on Oxidative Stress in Hashimoto Disease
    Study Start Date :
    Apr 1, 2010
    Actual Primary Completion Date :
    Apr 1, 2010
    Actual Study Completion Date :
    Oct 1, 2010

    Arms and Interventions

    Arm Intervention/Treatment
    healthy
    euthyroid hashimoto
    hypothyroid hashimoto

    Outcome Measures

    Primary Outcome Measures

    1. Poxidative stress markers [After levotren therapy]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 95 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • age more than 18 years
    Exclusion Criteria:

    • inability to give a written consent

    • other conditions and drug usage affect oxidative stress

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Vakif Gureba Training and Research Hospital Istanbul Turkey 34100

    Sponsors and Collaborators

    • Vakif Gureba Training and Research Hospital

    Investigators

    • Study Chair: Mehmet ali Cikrikcioglu, MD, vakif gureba TRH,fatih,istanbul,turkey.specialist in internal medicine

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Mehmet Ali Cikrikcioglu, Vakif Gureba TRH, Vakif Gureba Training and Research Hospital
    ClinicalTrials.gov Identifier:
    NCT01102205
    Other Study ID Numbers:
    • tastoshashi
    First Posted:
    Apr 13, 2010
    Last Update Posted:
    Jun 13, 2013
    Last Verified:
    Jun 1, 2013
    Additional relevant MeSH terms:
    Hashimoto Disease

    Study Results

    No Results Posted as of Jun 13, 2013