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Oxygen Uptake in Weaning of Patients From Prolonged Mechanical Ventilation

Sponsor
National Taiwan University Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT03433105
Collaborator
(none)
157
Enrollment
1
Location
30.7
Actual Duration (Months)
5.1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

1.Research hypothesis: during weaning patient from prolonged mechanical ventilation, if the work load caused by weaning was below the patient's AT, oxygen uptake will be constant. Otherwise, if the work load was above the patient's AT, the oxygen uptake will increase.

  1. Patient: who have tracheostomy tubes and with prolonged mechanical ventilation

  2. Measurement: oxygen uptake(V̇O2) and respiratory mechanics during the spontaneous breathing trials

  3. Outcome: Correlation between the oxygen uptake(V̇O2) and the weaning outcome

2.Specific aims:

  1. to investigate the prognostic value of oxygen uptake in weaning patients from prolonged mechanical ventilation

  2. Subgroup analysis may suggest which weaning protocol potentially benefit the most for each population group (cardiovascular disease, chronic pulmonary disease, neuromuscular disease, cerebrovascular disease)

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    157 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    To Investigate the Prognostic Value of Oxygen Uptake in Weaning of Patients From Prolonged Mechanical Ventilation
    Actual Study Start Date :
    Jan 23, 2018
    Actual Primary Completion Date :
    Aug 14, 2020
    Actual Study Completion Date :
    Aug 14, 2020

    Arms and Interventions

    Arm Intervention/Treatment
    1/patients with tracheostomy tubes and prolonged MV use

    Patients who have tracheostomy tubes and with prolonged mechanical ventilation

    Outcome Measures

    Primary Outcome Measures

    1. Measurement of oxygen uptake (V̇O2) [up to 12 hours during the spontaneous breathing trial]

      oxygen uptake during the spontaneous breathing trial

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years to 100 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    1. Inclusion criteria:

    Adult >20 y/o Total duration of mechanical ventilation ≥ 10 days Received tracheostomy Defervescence Meeting the criteria of weaning phase (see supplementary protocols)

    1. Exclusion criteria FiO2 >50 % Unstable hemodynamics Fever with active infection No spontaneous respiratory drive Dynamic airway collapse

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 National Taiwan University Hospital Taipei Taiwan 100

    Sponsors and Collaborators

    • National Taiwan University Hospital

    Investigators

    • Principal Investigator: Yao-Wen Kuo, MD, National Taiwan University Hospital

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    National Taiwan University Hospital
    ClinicalTrials.gov Identifier:
    NCT03433105
    Other Study ID Numbers:
    • 201710003RINB
    First Posted:
    Feb 14, 2018
    Last Update Posted:
    Oct 8, 2020
    Last Verified:
    Sep 1, 2019
    Keywords provided by National Taiwan University Hospital
    oxygen uptake
    prolonged mechanical ventilation
    weaning

    Study Results

    No Results Posted as of Oct 8, 2020