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p450 Mediated Lung Toxicity

Sponsor
National Institute of Environmental Health Sciences (NIEHS) (NIH)
Overall Status
Completed
CT.gov ID
NCT00023114
Collaborator
(none)
10
Enrollment
12
Duration (Months)

Study Details

Study Description

Brief Summary

The purpose of this project is to do cross species comparisons of the metabolism and toxicity of a number of toxicants which require metabolism for toxicity. All of the toxicants in question are encountered by humans in the workplace, through lifestyle choices (cigarette smoking) and as a result of environmental contamination. The high incidence of pulmonary diseases in the human population means that it will be difficult if not impossible to determine whether humans are at risk from exposure to these chemicals without solid mechanistic data. Recent rodent bioassays suggest that these compounds have oncogenic potential further supporting the need to test the potential for injury in primates. As part of this testing, we intend to establish in vitro methods for assessing critical steps in the metabolism of these agents and their interaction with cellular macromolecules. Once this is done, similar studies can be conducted in Rhesus or in human lung tissue that is available because it cannot be used for transplant purposes.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Study Start Date :
    Sep 1, 2000
    Study Completion Date :
    Sep 1, 2001

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      0 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No

      All available organ donors in the Sacramento area

      Contacts and Locations

      Locations

      No locations specified.

      Sponsors and Collaborators

      • National Institute of Environmental Health Sciences (NIEHS)

      Investigators

      None specified.

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00023114
      Other Study ID Numbers:
      • 8408-CP-001
      First Posted:
      Aug 24, 2001
      Last Update Posted:
      Sep 4, 2006
      Last Verified:
      Sep 1, 2006
      Keywords provided by , ,
      lung function
      smoking
      metabolism
      Additional relevant MeSH terms:
      Lung Diseases

      Study Results

      No Results Posted as of Sep 4, 2006