PaCIFiC-CUP Classifies Cancer of Unknown Primary
Study Details
Study Description
Brief Summary
This study aims to initially utilize machine learning on pan-cancer DNA methylation data from public databases to construct a DNA methylation classification model (PaCIFiC-CUP, pan-cancer integrated fingerprinting classifier of CUP) for diagnosing various types of cancer, particularly the primary site of cancer of unknown primary. The goal is to achieve diagnosis of cancer pathology type by analyzing the DNA methylation patterns of cancer specimens, thereby guiding subsequent precision treatment for cancer.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Site-Specific Therapy Group These patients with cancer of unknown primary received site-specific therapy that matched the particular site predicted by the DNA methylation classifier. |
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| Empirical Therapy Group These patients with cancer of unknown primary received empirical therapy that didn't match the particular site predicted by the DNA methylation classifier. |
Outcome Measures
Primary Outcome Measures
- Overall Survival [From date of diagnosis until the date of death from any cause, assessed up to 24 months]
Overall survival refers to the length of time that a person lives after being diagnosed with cancer of unknown primary, without regard to any specific cause of death.
Secondary Outcome Measures
- Progression-Free Survival [From date of diagnosis until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 24 months]
Progression-Free Survival refers to the length of time during which a patient with cancer of unknown primary remains alive without any signs or symptoms of disease progression
Eligibility Criteria
Criteria
Inclusion Criteria:
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The patient specimens were obtained from the Sun Yat-sen University Cancer Center and affiliated cooperating centers, with written consent from the patients authorizing the use of the specimens for research purposes.
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Following standard assessments (medical history, physical examination, complete blood count, biochemistry, computed tomography scans of the neck, chest, abdomen, and pelvis, targeted evaluations of all symptomatic areas, pathology, and immunohistochemistry), the diagnosis was determined as a primary site unknown tumor (including adenocarcinoma, squamous cell carcinoma, undifferentiated carcinoma, neuroendocrine carcinoma, sarcoma, etc).
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The diagnosis was confirmed at the participating institution and the patient had received systemic therapy.
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Complete clinical, pathological, and follow-up data for the patients can be obtained.
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ECOG performance status score: 0-2 points.
Exclusion Criteria:
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Pregnant or lactating female patients.
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Tumor tissue sample size is too small (tumor tissue accounts for <70% in the biopsy or slice tissue).
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Organ transplant or history of non-autologous (allogeneic) bone marrow or stem cell transplantation.
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History of previous tumors, with the current condition being a recurrent tumor.
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Hematological malignancies (excluding lymphoma).
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Other diseases that may severely impact patient survival, such as severe cardiovascular or cerebrovascular diseases, sepsis, severe trauma or burns, etc.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Sun Yat-sen university cancer center | Guangzhou | Guangdong | China | 510060 |
Sponsors and Collaborators
- Sun Yat-sen University
- First People's Hospital of Foshan
- Third Affiliated Hospital, Sun Yat-Sen University
- The First Affiliated Hospital of Anhui Medical University
- Anhui Provincial Cancer Hospital
- Dongguan People's Hospital
- Beijing Tongren Hospital
- Anhui Provincial Hospital
- Peking University Third Hospital
- Henan Cancer Hospital
- Ganzhou Cancer Hospital
- Guangzhou Chest Hospital.
- First Affiliated Hospital of Jinan University
- Peking University Shenzhen Hospital
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- PaCIFiC-CUP