Clincosm LogoSign in Get a demo

PAI-1 Expression in Non-scarring Hair Loss

Sponsor
Northwestern University (Other)
Overall Status
Terminated
CT.gov ID
NCT02548689
Collaborator
(none)
10
Enrollment
1
Location
71
Duration (Months)
0.1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study will investigate whether subjects who suffer from hair loss have increased levels of PAI-1 compared to age-matched control subjects. The level of PAI-1 expression will be determined in subjects without hair loss and in subjects with non-scarring hair loss, including androgenetic alopecia, telogen effluvium and alopecia areata.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    This study will compare the levels of PAI-1 expression in subjects with different forms of non-scarring hair loss and in these subjects vs normal age-matched controls. Hair loss subjects will have their Northwestern Memorial Hospital and Northwestern Medical Faculty Foundation medical records reviewed to ensure they meet inclusion and exclusion criteria. All subjects will have a 4 mm punch biopsy on the scalp. Tissue PAI-1 levels from scalp skin biopsies will be determined by immunohistochemical staining. Samples will be kept for approximately 15 years, after which time unused samples will be destroyed.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    10 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Cross-Sectional
    Official Title:
    Evaluating PAI-1 Expression in the Hair Follicles of Patients With Non-scarring Hair Loss.
    Study Start Date :
    Jul 1, 2015
    Actual Primary Completion Date :
    Jun 1, 2021
    Actual Study Completion Date :
    Jun 1, 2021

    Arms and Interventions

    Arm Intervention/Treatment
    Non-scarring hair loss

    Patients seen at Northwestern Memorial Hospital or Northwestern Medical Faculty Foundation physician offices that have undergone evaluation for hair loss and have a diagnosis of androgenetic alopecia, telogen effluvium or alopecia areata.
    Control

    Age-matched controls who do not have a history of hair loss and have normal scalp skin without evidence of hair loss.

    Outcome Measures

    Primary Outcome Measures

    1. PAI-1 expression level in scalp skin biopsy samples [Baseline]

      Tissue PAI-1 expression levels will be determined by immunohistochemistry, a three-layer biotin-strepavidin system. Positive PAI-1 expression per total tissue area will be quantified using the color-picker function in imaging software.The PAI-1 expression found in normal scalps will be compared to those found in scalps with hair loss.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 60 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • Age-matched control subjects who do not have a history of hair loss

    • A clinical and pathologic diagnosis of androgenetic alopecia, telogen effluvium, alopecia areata or normal scalp skin

    • All subjects must have given signed, informed consent prior to registration in study

    Exclusion Criteria:

    • History of previous hair transplantation

    • Current and past use of medications topically on the scalp

    • Clinical or pathologic diagnosis of a scarring alopecia

    • History of inflammatory conditions of the scalp such as psoriasis

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Northwestern University Department of Dermatology Chicago Illinois United States 60611

    Sponsors and Collaborators

    • Northwestern University

    Investigators

    • Principal Investigator: Maria Colavincenzo, MD, Northwestern University Feinberg School of Medicine

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    Responsible Party:
    Maria Colavincenzo, Assistant Professor in Dermatology, Northwestern University
    ClinicalTrials.gov Identifier:
    NCT02548689
    Other Study ID Numbers:
    • STU00103009
    First Posted:
    Sep 14, 2015
    Last Update Posted:
    Jun 9, 2022
    Last Verified:
    Jun 1, 2022
    Keywords provided by Maria Colavincenzo, Assistant Professor in Dermatology, Northwestern University
    alopecia
    hair loss
    Additional relevant MeSH terms:
    Alopecia
    Alopecia Areata

    Study Results

    No Results Posted as of Jun 9, 2022