Effects of Static Apnea at High Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function
Study Details
Study Description
Brief Summary
The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent static apneas training session at high lung volume in healthy subjects; also, as secondary objectives, to analyze the cardiovascular and respiratory response produced during the intervention.
Condition or Disease | Intervention/Treatment | Phase |
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Phase 3 |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: Static apnea at High Lung Volume Participants will remain at rest in the supine position for 6 minutes. Participants in the experimental group will perform intermittent apneas at high lung volume with a density of 30 seconds, followed by a normal breath of 10 seconds (9 cycles of 30s apnea - 10s normal breathing, until completing the 6 minutes). |
Other: Voluntary apnoea
Static apneas at high lung volume with a density of 30 seconds, followed by a normal breath of 10 seconds (9 cycles of 30s apnea - 10s normal breathing, until completing the 6 minutes).
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No Intervention: Static at normal breathing Participants will remain at rest in the supine position for 6 minutes. Participants in the control group will remain breathing normally for these 6 minutes |
Outcome Measures
Primary Outcome Measures
- Pain pressure threshold (PPT) on thumb, anterior tibial and spinous process of C7 [before and after intervention (up 30 minutes)]
PPT is tested on the dorsal base of the distal phalanx of the thumb on the dominant side and on the muscle belly of the tibialis anterior on the dominant side. The region to be pressed is marked with a pen. The patient is instructed to report with the first appearance of the sensation of "discomfort". An ascending ramp of 0.5 kg/cm/s is applied, at the rhythm of a metronome. The measurement is started on the thumb, and alternated with tibia and C7 until 3 measurements of each region are obtained, enough time to give 30 seconds of rest between measurements in the same region. This protocol has demonstrated high inter-observer reliability measuring healthy subjects (ICC = 0.91).
Secondary Outcome Measures
- Perceived Stress Scale (PSS) [before intervention (up 5 minutes)]
14-item questionnaire about their thoughts and feelings in the last month. The scale has a range of scores from 0 to 56. The lower the score, the more favorable for the patient's health.
- Pittsburg Sleep Quality Index (PSQI) [before intervention (up 5 minutes)]
9-item questionnaire on sleep quality in the past month. The scale has a range of scores from 0 to 21. The lower the score, the more favorable for the patient's health.
- Global Physical Activity Questionnaire (GPAQ) [before intervention (up 5 minutes)]
6-item questionnaire on the level of physical activity at work, for commuting and in leisure time. A higher score means higher weekly physical activity
- Oxygen saturation [during intervention (up 6 minutes)]
Oxygen saturation will be measured during the procedure by finger pulse oximetry.
- Heart rate [during intervention (up 6 minutes)]
Heart rate will be measured during the procedure by finger pulse oximetry.
- Blood pressure [before, during and after intervention (up 10 minutes)]
Systolic and diastolic blood pressure will be measured before, during and immediately after the procedure using a digital wrist sphygmomanometer.
- Rate of perceived exertion (RPE) [immediately after intervention (up 10 seconds)]
RPE Borg CR-10 is used to measure how hard your body works during physical activity. It runs from 0 - 10, using numbers to rate how much effort an activity takes.
Eligibility Criteria
Criteria
Inclusion Criteria:
- Asymptomatic subjects aged between 18 and 64 years.
Exclusion Criteria:
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Cardiovascular, respiratory, metabolic, neurological or osteomuscular signs or pathologies.
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History of epilepsy.
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Pregnant.
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Pharmacological treatment.
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Participants who present any type of pain on the day of the measurements or who have frequently suffered pain during the previous 4 weeks.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | CSEU LaSalle | Madrid | Spain |
Sponsors and Collaborators
- Centro Universitario La Salle
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CSEULS-PI-015/2023