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Comparing Two Methods to Follow Patients With Pancreatic Cysts

Sponsor
ECOG-ACRIN Cancer Research Group (Other)
Overall Status
Recruiting
CT.gov ID
NCT04239573
Collaborator
National Cancer Institute (NCI) (NIH)
4,606
Enrollment
300
Locations
2
Arms
157.9
Anticipated Duration (Months)
15.4
Patients Per Site
0.1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to compare the two approaches for monitoring pancreatic cysts. The study doctors want to compare more frequent monitoring vs less frequent monitoring in order to learn which monitoring method leads to better outcome for patients with pancreatic cysts.

Condition or Disease Intervention/Treatment Phase
  • Procedure: Computed Tomography
  • Procedure: Endoscopic Ultrasound
  • Procedure: Magnetic Resonance Imaging
  • Other: Quality-of-Life Assessment
  • Other: Questionnaire Administration
 N/A

Detailed Description

PRIMARY OBJECTIVES:
  1. To compare the rates of unfavorable clinical outcomes in the two arms.
SECONDARY OBJECTIVES:

  1. To compare rates of major surgical morbidity and/or mortality between arms. II. To compare pancreatic cancer incidence and all-cause mortality across arms. III. Compare institutional (direct) costs. IV. Compare healthcare utilization of imaging, invasive testing, surgical, and other procedures across the two surveillance arms.

  2. Compare patient (out-of-pocket and other indirect) costs. VI. Describe diagnostic test and treatment pathways by arm. VII. Compare patient reports of quality of life (QOL), situational anxiety. VIII. Compare patient report of financial distress. IX. Compare rates of non-adherence by arm assignment. X. To evaluate and compare the predictive performance of known and future biomarkers for dysplasia or cancer.

EXPLORATORY OBJECTIVE:
  1. To evaluate and compare the predictive accuracy of known and future radiomic markers for dysplasia and pancreatic cancer.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM A (LOW INTENSITY SURVEILLANCE): Patients undergo magnetic resonance imaging (MRI) or computed tomography (CT) at the beginning of the trial and again in 1 year. Following the first year, patients with no abnormalities repeat MRI or CT every 2 years. Patients with positive imaging features on MRI and CT at 1 or 2 years and with negative endoscopic ultrasound (EUS), repeat MRI or CT in 1 year. Patients with negative imaging repeat MRI or CT in 2 years.

ARM B (HIGH INTENSITY SURVEILLANCE): Patients undergo MRI or CT. Patients with 1-2 cm cyst undergo MRI or CT every 6 months for 1 year, then every 12 months for 2 years, and then every 24 months thereafter. Patients with 2-3 cm cyst undergo EUS within 6 months, and if EUS is negative, patients repeat MRI or CT in 1 year. If second EUS is negative, patients undergo alternate MRI or CT and EUS every 12 months. Patients with cyst > 3 cm undergo EUS within 6 months, and if EUS is negative, patients undergo alternate MRI or CT with EUS every 3-6 months.

After completion of imaging procedures, patients are followed up for 5 years from the date of registration .

Study Design

Study Type:
Interventional
Anticipated Enrollment :
4606 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Supportive Care
Official Title:
Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs
Actual Study Start Date :
Jan 16, 2020
Anticipated Primary Completion Date :
Mar 15, 2031
Anticipated Study Completion Date :
Mar 15, 2033

Arms and Interventions

Arm Intervention/Treatment
Experimental: Arm I (low intensity surveillance)

Patients undergo MRI or CT at the beginning of the trial and again in 1 year. Following the first year, patients with no abnormalities repeat MRI or CT every 2 years. Patients with positive imaging features on MRI and CT at 1 or 2 years and with negative EUS, repeat MRI or CT in 1 year. Patients with negative imaging repeat MRI or CT in 2 years.

Procedure: Computed Tomography
Undergo CT
Other Names:
  • CAT
  • CAT scan
  • Computerized Axial Tomography
  • computerized tomography
  • CT
  • CT scan
  • tomography

    • Procedure: Endoscopic Ultrasound
    Undergo EUS
    Other Names:
  • endosonography
  • EUS

    • Procedure: Magnetic Resonance Imaging
    Undergo MRI
    Other Names:
  • Magnetic Resonance Imaging Scan
  • Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance
  • MR Imaging
  • MRI
  • MRI Scan
  • NMR Imaging
  • NMRI
  • nuclear magnetic resonance imaging

    • Other: Quality-of-Life Assessment
    Ancillary studies
    Other Names:
  • Quality of Life Assessment

    • Other: Questionnaire Administration
    Ancillary studies
    Experimental: Arm II (high intensity surveillance)

    Patients undergo MRI or CT. Patients with 1-2 cm cyst undergo MRI or CT every 6 months for 1 year, then every 12 months for 2 years, and then every 24 months thereafter. Patients with 2-3 cm cyst undergo EUS within 6 months, and if EUS is negative, patients repeat MRI or CT in 1 year. If second EUS is negative, patients undergo alternate MRI or CT and EUS every 12 months. Patients with cyst > 3 cm undergo EUS within 6 months, and if EUS is negative, patients undergo alternate MRI or CT with EUS every 3-6 months.

    Procedure: Computed Tomography
    Undergo CT
    Other Names:
  • CAT
  • CAT scan
  • Computerized Axial Tomography
  • computerized tomography
  • CT
  • CT scan
  • tomography

    • Procedure: Endoscopic Ultrasound
    Undergo EUS
    Other Names:
  • endosonography
  • EUS

    • Procedure: Magnetic Resonance Imaging
    Undergo MRI
    Other Names:
  • Magnetic Resonance Imaging Scan
  • Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance
  • MR Imaging
  • MRI
  • MRI Scan
  • NMR Imaging
  • NMRI
  • nuclear magnetic resonance imaging

    • Other: Quality-of-Life Assessment
    Ancillary studies
    Other Names:
  • Quality of Life Assessment

    • Other: Questionnaire Administration
    Ancillary studies

    Outcome Measures

    Primary Outcome Measures

    1. Occurrence of an "unfavorable" outcome [Up to 5 years]

      Defined as a composite of: (1) any pancreatic cancer without surgery; (2) unresectable pancreatic cancer or cancer > T1a, N0 at surgery, and (3) benign disease at surgery will be approached from the intent-to-treat perspective. Time to the first occurrence of the primary endpoint will measured from randomization. Survival analysis methods will be used to estimate and compare distributions of time to an unfavorable event between the study arms. In particular Kaplan-Meier estimates will be developed for each arm and a log rank test will be used to compare the two arms.

    Secondary Outcome Measures

    1. Surgical and all-cause mortality [Up to 5 years]

      Rates of major surgical morbidity and/or mortality will be estimated and compared across arms. All-cause mortality will be estimated and compared between the arms using log rank tests.

    2. Major surgical morbidity [Up to 5 years]

      Rates of major surgical morbidity and/or mortality will be estimated and compared across arms.

    3. Pancreatic cancer incidence [Up to 5 years]

      Pancreatic-cancer incidence and pancreatic cancer specific mortality will be estimated and compared between the arms using log rank tests.

    4. Healthcare utilization of imaging, invasive testing, surgical, and other procedures using information collected from sites. [Up to 5 years]

      Will compare between two arms.

    5. Patient (out-of-pocket and other indirect) costs collected from patient surveys [Up to 5 years]

      Will compare between two arms.

    6. Patient reports of quality of life [Up to 5 years]

      Will be assessed by Patient Reported Outcomes Measurement Information System10. Will compare between arms. Longitudinal regression modelling will be completed to account for the repeated assessments over time.

    7. Patient reports of situational anxiety [Up to 5 years]

      Will be assessed by Patient Reported Outcomes Measurement Information System-Anxiety short form. Will compare between arms.

    8. Patient report of financial distress collected through patient surveys [Up to 5 years]

      Will compare between arms.

    9. Rates of non-adherence [Up to 5 years]

      Will compare rates of non-adherence by arm assignment.

    10. Biomarker analysis from collected samples to compare the predictive performance of known and future biomarkers for dysplasia or cancer [Up to 5 years]

      Will evaluate and compare the predictive performance of known and future biomarkers for dysplasia or cancer.

    Other Outcome Measures

    1. Predictive accuracy of radiomic markers for dysplasia and pancreatic cancer [Up to 5 years]

      Will evaluate and compare the predictive accuracy of known and future radiomic markers for dysplasia and pancreatic cancer.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    50 Years to 75 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1

    • Patient must not have acute pancreatitis or a history of chronic pancreatitis

    • Patient must have received a computed tomography (CT) or magnetic resonance imaging (MRI) within 3 months of registration that revealed a newly identified >= 1 cm pancreatic cyst

    • Women of childbearing potential must not be known to be pregnant

    • Patient must not have a prior diagnosis of pancreatic cyst or pancreatic malignancy of any type

    • Patient must not have a history of pancreatic resection

    • Patient must not have other asymptomatic pancreatic cystic lesion with zero/low malignancy potential (pancreatic pseudocyst, classic serous cystic lesion) on index CT or MRI

    • Patient must not have a family history of pancreatic adenocarcinoma in 1 or more first degree relatives

    • Patient must not have pancreatic cyst morphology that would prompt immediate surgical consideration (enhancing mural nodule, solid component in cyst, pancreatic duct > 10 mm, cyst causing obstructive jaundice)

    • Patient must not have a comorbid illness that precludes pancreatic cyst resection

    • Patient must not be participating in an already established surveillance program

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 University of Alabama at Birmingham Cancer Center Birmingham Alabama United States 35233
    2 University of South Alabama Mitchell Cancer Institute Mobile Alabama United States 36688
    3 Anchorage Associates in Radiation Medicine Anchorage Alaska United States 98508
    4 Anchorage Radiation Therapy Center Anchorage Alaska United States 99504
    5 Alaska Breast Care and Surgery LLC Anchorage Alaska United States 99508
    6 Alaska Oncology and Hematology LLC Anchorage Alaska United States 99508
    7 Alaska Women's Cancer Care Anchorage Alaska United States 99508
    8 Anchorage Oncology Centre Anchorage Alaska United States 99508
    9 Katmai Oncology Group Anchorage Alaska United States 99508
    10 Providence Alaska Medical Center Anchorage Alaska United States 99508
    11 Mayo Clinic Hospital in Arizona Phoenix Arizona United States 85054
    12 Mayo Clinic in Arizona Scottsdale Arizona United States 85259
    13 University of Arkansas for Medical Sciences Little Rock Arkansas United States 72205
    14 Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California United States 91505
    15 Enloe Medical Center Chico California United States 95926
    16 UC San Diego Moores Cancer Center La Jolla California United States 92093
    17 UCSF Medical Center-Mount Zion San Francisco California United States 94115
    18 UCSF Medical Center-Parnassus San Francisco California United States 94143
    19 UCSF Medical Center-Mission Bay San Francisco California United States 94158
    20 Smilow Cancer Hospital-Derby Care Center Derby Connecticut United States 06418
    21 Smilow Cancer Hospital Care Center-Fairfield Fairfield Connecticut United States 06824
    22 Smilow Cancer Hospital Care Center at Glastonbury Glastonbury Connecticut United States 06033
    23 Smilow Cancer Hospital Care Center at Greenwich Greenwich Connecticut United States 06830
    24 Smilow Cancer Hospital Care Center - Guiford Guilford Connecticut United States 06437
    25 Smilow Cancer Hospital-Hamden Care Center Hamden Connecticut United States 06518
    26 Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut United States 06105
    27 Smilow Cancer Center/Yale-New Haven Hospital New Haven Connecticut United States 06510
    28 Yale-New Haven Hospital Saint Raphael Campus New Haven Connecticut United States 06511
    29 Yale University New Haven Connecticut United States 06520
    30 Yale-New Haven Hospital North Haven Medical Center North Haven Connecticut United States 06473
    31 Smilow Cancer Hospital-Orange Care Center Orange Connecticut United States 06477
    32 Smilow Cancer Hospital-Torrington Care Center Torrington Connecticut United States 06790
    33 Smilow Cancer Hospital Care Center-Trumbull Trumbull Connecticut United States 06611
    34 Smilow Cancer Hospital-Waterbury Care Center Waterbury Connecticut United States 06708
    35 Smilow Cancer Hospital Care Center - Waterford Waterford Connecticut United States 06385
    36 Veterans Affairs Connecticut Healthcare System-West Haven Campus West Haven Connecticut United States 06516
    37 MedStar Georgetown University Hospital Washington District of Columbia United States 20007
    38 Regional Cancer Center-Lee Memorial Health System Fort Myers Florida United States 33905
    39 Emory University Hospital Midtown Atlanta Georgia United States 30308
    40 Emory University Hospital/Winship Cancer Institute Atlanta Georgia United States 30322
    41 Emory Saint Joseph's Hospital Atlanta Georgia United States 30342
    42 Saint Luke's Cancer Institute - Boise Boise Idaho United States 83712
    43 Saint Luke's Cancer Institute - Fruitland Fruitland Idaho United States 83619
    44 Saint Luke's Cancer Institute - Meridian Meridian Idaho United States 83642
    45 Saint Luke's Cancer Institute - Nampa Nampa Idaho United States 83686
    46 Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho United States 83301
    47 Advocate Good Shepherd Hospital Barrington Illinois United States 60010
    48 Bromenn Lifecare Center Bloomington Illinois United States 61701
    49 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    50 Illinois CancerCare-Canton Canton Illinois United States 61520
    51 Memorial Hospital of Carbondale Carbondale Illinois United States 62902
    52 SIH Cancer Institute Carterville Illinois United States 62918
    53 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    54 Centralia Oncology Clinic Centralia Illinois United States 62801
    55 Northwestern University Chicago Illinois United States 60611
    56 Advocate Illinois Masonic Medical Center Chicago Illinois United States 60657
    57 AMG Crystal Lake - Oncology Crystal Lake Illinois United States 60014
    58 Carle on Vermilion Danville Illinois United States 61832
    59 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    60 Decatur Memorial Hospital Decatur Illinois United States 62526
    61 Northwestern Medicine Cancer Center Kishwaukee DeKalb Illinois United States 60115
    62 Illinois CancerCare-Dixon Dixon Illinois United States 61021
    63 Advocate Good Samaritan Hospital Downers Grove Illinois United States 60515
    64 Carle Physician Group-Effingham Effingham Illinois United States 62401
    65 Crossroads Cancer Center Effingham Illinois United States 62401
    66 Advocate Sherman Hospital Elgin Illinois United States 60123
    67 Elmhurst Memorial Hospital Elmhurst Illinois United States 60126
    68 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    69 NorthShore University HealthSystem-Evanston Hospital Evanston Illinois United States 60201
    70 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    71 Western Illinois Cancer Treatment Center Galesburg Illinois United States 61401
    72 Northwestern Medicine Cancer Center Delnor Geneva Illinois United States 60134
    73 NorthShore University HealthSystem-Glenbrook Hospital Glenview Illinois United States 60026
    74 Ingalls Memorial Hospital Harvey Illinois United States 60426
    75 Advocate South Suburban Hospital Hazel Crest Illinois United States 60429
    76 NorthShore University HealthSystem-Highland Park Hospital Highland Park Illinois United States 60035
    77 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    78 Northwestern Medicine Lake Forest Hospital Lake Forest Illinois United States 60045
    79 AMG Libertyville - Oncology Libertyville Illinois United States 60048
    80 Condell Memorial Hospital Libertyville Illinois United States 60048
    81 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    82 Carle Physician Group-Mattoon/Charleston Mattoon Illinois United States 61938
    83 Edward Hospital/Cancer Center Naperville Illinois United States 60540
    84 Bromenn Regional Medical Center Normal Illinois United States 61761
    85 Carle Cancer Institute Normal Normal Illinois United States 61761
    86 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    87 Advocate Christ Medical Center Oak Lawn Illinois United States 60453-2699
    88 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    89 Advocate Lutheran General Hospital Park Ridge Illinois United States 60068
    90 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    91 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    92 Methodist Medical Center of Illinois Peoria Illinois United States 61636
    93 Illinois CancerCare-Peru Peru Illinois United States 61354
    94 Valley Radiation Oncology Peru Illinois United States 61354
    95 Edward Hospital/Cancer Center?Plainfield Plainfield Illinois United States 60585
    96 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    97 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    98 Springfield Clinic Springfield Illinois United States 62702
    99 Memorial Medical Center Springfield Illinois United States 62781
    100 Southwest Illinois Health Services LLP Swansea Illinois United States 62226
    101 Carle Cancer Center Urbana Illinois United States 61801
    102 The Carle Foundation Hospital Urbana Illinois United States 61801
    103 Northwestern Medicine Cancer Center Warrenville Warrenville Illinois United States 60555
    104 Illinois CancerCare - Washington Washington Illinois United States 61571
    105 Reid Health Richmond Indiana United States 47374
    106 University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa United States 52242
    107 LSU Health Baton Rouge-North Clinic Baton Rouge Louisiana United States 70805
    108 Our Lady of The Lake Baton Rouge Louisiana United States 70808
    109 Mary Bird Perkins Cancer Center Baton Rouge Louisiana United States 70809
    110 Our Lady of the Lake Physicians Group - Medical Oncology Baton Rouge Louisiana United States 70809
    111 UM Baltimore Washington Medical Center/Tate Cancer Center Glen Burnie Maryland United States 21061
    112 University of Michigan Comprehensive Cancer Center Ann Arbor Michigan United States 48109
    113 Bronson Battle Creek Battle Creek Michigan United States 49017
    114 Beaumont Hospital - Dearborn Dearborn Michigan United States 48124
    115 Beaumont Hospital - Farmington Hills Farmington Hills Michigan United States 48336
    116 Helen DeVos Children's Hospital at Spectrum Health Grand Rapids Michigan United States 49503
    117 Mercy Health Saint Mary's Grand Rapids Michigan United States 49503
    118 Spectrum Health at Butterworth Campus Grand Rapids Michigan United States 49503
    119 Bronson Methodist Hospital Kalamazoo Michigan United States 49007
    120 West Michigan Cancer Center Kalamazoo Michigan United States 49007
    121 Ascension Borgess Cancer Center Kalamazoo Michigan United States 49009
    122 Borgess Medical Center Kalamazoo Michigan United States 49048
    123 Mercy Health Mercy Campus Muskegon Michigan United States 49444
    124 Lakeland Hospital Niles Niles Michigan United States 49120
    125 Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan United States 49444
    126 Spectrum Health Reed City Hospital Reed City Michigan United States 49677
    127 Oakland Colon Rectal Associates Royal Oak Michigan United States 48067
    128 Cancer Care Associates PC Royal Oak Michigan United States 48073
    129 Comprehensive Medical Center PLLC Royal Oak Michigan United States 48073
    130 Hematology Oncology Consultants PC Royal Oak Michigan United States 48073
    131 Oakland Medical Group Royal Oak Michigan United States 48073
    132 William Beaumont Hospital-Royal Oak Royal Oak Michigan United States 48073
    133 Lakeland Medical Center Saint Joseph Saint Joseph Michigan United States 49085
    134 Marie Yeager Cancer Center Saint Joseph Michigan United States 49085
    135 Munson Medical Center Traverse City Michigan United States 49684
    136 Michigan Institute of Urology-Town Center Troy Michigan United States 48084
    137 William Beaumont Hospital - Troy Troy Michigan United States 48085
    138 Hematology Oncology Consultants PC-Troy Troy Michigan United States 48098
    139 Metro Health Hospital Wyoming Michigan United States 49519
    140 Sanford Joe Lueken Cancer Center Bemidji Minnesota United States 56601
    141 Sanford Thief River Falls Medical Center Thief River Falls Minnesota United States 56701
    142 Sanford Cancer Center Worthington Worthington Minnesota United States 56187
    143 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    144 Southeast Cancer Center Cape Girardeau Missouri United States 63703
    145 Parkland Health Center - Farmington Farmington Missouri United States 63640
    146 Capital Region Southwest Campus Jefferson City Missouri United States 65109
    147 Washington University School of Medicine Saint Louis Missouri United States 63110
    148 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    149 Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri United States 63670
    150 Missouri Baptist Sullivan Hospital Sullivan Missouri United States 63080
    151 Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri United States 63127
    152 Saint Patrick Hospital - Community Hospital Missoula Montana United States 59802
    153 Dartmouth Hitchcock Medical Center Lebanon New Hampshire United States 03756
    154 CentraState Medical Center Freehold New Jersey United States 07728
    155 Morristown Medical Center Morristown New Jersey United States 07960
    156 Capital Health Medical Center-Hopewell Pennington New Jersey United States 08534
    157 Overlook Hospital Summit New Jersey United States 07902
    158 University of New Mexico Cancer Center Albuquerque New Mexico United States 87102
    159 Montefiore Medical Center-Einstein Campus Bronx New York United States 10461
    160 Montefiore Medical Center-Weiler Hospital Bronx New York United States 10461
    161 Montefiore Medical Center - Moses Campus Bronx New York United States 10467
    162 Roswell Park Cancer Institute Buffalo New York United States 14263
    163 Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York United States 10016
    164 East Carolina University Greenville North Carolina United States 27834
    165 Sanford Bismarck Medical Center Bismarck North Dakota United States 58501
    166 Sanford South University Medical Center Fargo North Dakota United States 58103
    167 Southpointe-Sanford Medical Center Fargo Fargo North Dakota United States 58103
    168 Sanford Medical Center Fargo Fargo North Dakota United States 58104
    169 Sanford Broadway Medical Center Fargo North Dakota United States 58122
    170 Sanford Roger Maris Cancer Center Fargo North Dakota United States 58122
    171 Indu and Raj Soin Medical Center Beavercreek Ohio United States 45431
    172 Saint Elizabeth Boardman Hospital Boardman Ohio United States 44512
    173 Dayton Physicians LLC-Miami Valley South Centerville Ohio United States 45459
    174 Miami Valley Hospital South Centerville Ohio United States 45459
    175 Oncology Hematology Care Inc-Kenwood Cincinnati Ohio United States 45236
    176 MetroHealth Medical Center Cleveland Ohio United States 44109
    177 Ohio State University Comprehensive Cancer Center Columbus Ohio United States 43210
    178 Miami Valley Hospital Dayton Ohio United States 45409
    179 Dayton Physician LLC-Miami Valley Hospital North Dayton Ohio United States 45415
    180 Miami Valley Hospital North Dayton Ohio United States 45415
    181 Armes Family Cancer Center Findlay Ohio United States 45840
    182 Blanchard Valley Hospital Findlay Ohio United States 45840
    183 Orion Cancer Care Findlay Ohio United States 45840
    184 Atrium Medical Center-Middletown Regional Hospital Franklin Ohio United States 45005-1066
    185 Dayton Physicians LLC-Atrium Franklin Ohio United States 45005
    186 Dayton Physicians LLC-Wayne Greenville Ohio United States 45331
    187 Wayne Hospital Greenville Ohio United States 45331
    188 Greater Dayton Cancer Center Kettering Ohio United States 45409
    189 Kettering Medical Center Kettering Ohio United States 45429
    190 Springfield Regional Cancer Center Springfield Ohio United States 45504
    191 Springfield Regional Medical Center Springfield Ohio United States 45505
    192 Dayton Physicians LLC-Upper Valley Troy Ohio United States 45373
    193 Upper Valley Medical Center Troy Ohio United States 45373
    194 Saint Joseph Warren Hospital Warren Ohio United States 44484
    195 Saint Elizabeth Youngstown Hospital Youngstown Ohio United States 44501
    196 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    197 Saint Charles Health System Bend Oregon United States 97701
    198 Clackamas Radiation Oncology Center Clackamas Oregon United States 97015
    199 Providence Cancer Institute Clackamas Clinic Clackamas Oregon United States 97015
    200 Bay Area Hospital Coos Bay Oregon United States 97420
    201 Providence Newberg Medical Center Newberg Oregon United States 97132
    202 Providence Portland Medical Center Portland Oregon United States 97213
    203 Providence Saint Vincent Medical Center Portland Oregon United States 97225
    204 Oregon Health and Science University Portland Oregon United States 97239
    205 Saint Charles Health System-Redmond Redmond Oregon United States 97756
    206 Saint Luke's University Hospital-Bethlehem Campus Bethlehem Pennsylvania United States 18015
    207 Bryn Mawr Hospital Bryn Mawr Pennsylvania United States 19010
    208 Main Line Health Center-Collegeville Collegeville Pennsylvania United States 19426
    209 Geisinger Medical Center Danville Pennsylvania United States 17822
    210 Main Line Health Center-Exton Exton Pennsylvania United States 19341
    211 Riddle Memorial Hospital Media Pennsylvania United States 19063
    212 Paoli Memorial Hospital Paoli Pennsylvania United States 19301
    213 University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania United States 19104
    214 Fox Chase Cancer Center Philadelphia Pennsylvania United States 19111
    215 Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania United States 18711
    216 Lankenau Medical Center Wynnewood Pennsylvania United States 19096
    217 Smilow Cancer Hospital Care Center - Westerly Westerly Rhode Island United States 02891
    218 Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina United States 29316
    219 Roper Hospital Charleston South Carolina United States 29401
    220 Bon Secours Saint Francis Hospital Charleston South Carolina United States 29414
    221 Prisma Health Cancer Institute - Laurens Clinton South Carolina United States 29325
    222 Prisma Health Richland Hospital Columbia South Carolina United States 29203
    223 Prisma Health Baptist Hospital Columbia South Carolina United States 29220
    224 Prisma Health Cancer Institute - Easley Easley South Carolina United States 29640
    225 Tidelands Georgetown Memorial Hospital Georgetown South Carolina United States 29440
    226 Prisma Health Cancer Institute - Butternut Greenville South Carolina United States 29605
    227 Prisma Health Cancer Institute - Faris Greenville South Carolina United States 29605
    228 Prisma Health Greenville Memorial Hospital Greenville South Carolina United States 29605
    229 Prisma Health Cancer Institute - Eastside Greenville South Carolina United States 29615
    230 Prisma Health Cancer Institute - Greer Greer South Carolina United States 29650
    231 Prisma Health Cancer Institute - Seneca Seneca South Carolina United States 29672
    232 Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota United States 57104
    233 Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota United States 57117-5134
    234 University of Tennessee - Knoxville Knoxville Tennessee United States 37920
    235 Baptist Memorial Hospital and Cancer Center-Memphis Memphis Tennessee United States 38120
    236 Vanderbilt University/Ingram Cancer Center Nashville Tennessee United States 37232
    237 UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas United States 75390
    238 Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston Texas United States 77030
    239 Huntsman Cancer Institute/University of Utah Salt Lake City Utah United States 84112
    240 University of Virginia Cancer Center Charlottesville Virginia United States 22908
    241 VCU Massey Cancer Center at Stony Point Richmond Virginia United States 23235
    242 Virginia Commonwealth University/Massey Cancer Center Richmond Virginia United States 23298
    243 Valley Health / Winchester Medical Center Winchester Virginia United States 22601
    244 Providence Regional Cancer System-Aberdeen Aberdeen Washington United States 98520
    245 PeaceHealth Saint Joseph Medical Center Bellingham Washington United States 98225
    246 Providence Regional Cancer System-Centralia Centralia Washington United States 98531
    247 Swedish Cancer Institute-Edmonds Edmonds Washington United States 98026
    248 Providence Regional Cancer Partnership Everett Washington United States 98201
    249 Swedish Cancer Institute-Issaquah Issaquah Washington United States 98029
    250 Kadlec Clinic Hematology and Oncology Kennewick Washington United States 99336
    251 Providence Regional Cancer System-Lacey Lacey Washington United States 98503
    252 PeaceHealth Saint John Medical Center Longview Washington United States 98632
    253 Virginia Mason Medical Center Seattle Washington United States 98101
    254 Pacific Gynecology Specialists Seattle Washington United States 98104
    255 Swedish Medical Center-Ballard Campus Seattle Washington United States 98107
    256 Swedish Medical Center-First Hill Seattle Washington United States 98122-4307
    257 Swedish Medical Center-Cherry Hill Seattle Washington United States 98122-5711
    258 PeaceHealth United General Medical Center Sedro-Woolley Washington United States 98284
    259 Providence Regional Cancer System-Shelton Shelton Washington United States 98584
    260 PeaceHealth Southwest Medical Center Vancouver Washington United States 98664
    261 Providence Saint Mary Regional Cancer Center Walla Walla Washington United States 99362
    262 North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima Washington United States 98902
    263 Providence Regional Cancer System-Yelm Yelm Washington United States 98597
    264 United Hospital Center Bridgeport West Virginia United States 26330
    265 WVUH-Berkely Medical Center Martinsburg West Virginia United States 25401
    266 West Virginia University Healthcare Morgantown West Virginia United States 26506
    267 Camden Clark Medical Center Parkersburg West Virginia United States 26101
    268 Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin United States 53105
    269 Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin United States 54701
    270 Aurora Health Care Germantown Health Center Germantown Wisconsin United States 53022
    271 Aurora Cancer Care-Grafton Grafton Wisconsin United States 53024
    272 Aurora BayCare Medical Center Green Bay Wisconsin United States 54311
    273 Mercyhealth Hospital and Cancer Center - Janesville Janesville Wisconsin United States 53548
    274 Aurora Cancer Care-Kenosha South Kenosha Wisconsin United States 53142
    275 University of Wisconsin Carbone Cancer Center Madison Wisconsin United States 53792
    276 Aurora Bay Area Medical Group-Marinette Marinette Wisconsin United States 54143
    277 Marshfield Medical Center-Marshfield Marshfield Wisconsin United States 54449
    278 Aurora Cancer Care-Milwaukee Milwaukee Wisconsin United States 53209
    279 Aurora Saint Luke's Medical Center Milwaukee Wisconsin United States 53215
    280 Aurora Sinai Medical Center Milwaukee Wisconsin United States 53233
    281 Marshfield Clinic-Minocqua Center Minocqua Wisconsin United States 54548
    282 Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin United States 54904
    283 Aurora Cancer Care-Racine Racine Wisconsin United States 53406
    284 Marshfield Medical Center-Rice Lake Rice Lake Wisconsin United States 54868
    285 Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin United States 53081
    286 Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin United States 54482
    287 Aurora Medical Center in Summit Summit Wisconsin United States 53066
    288 Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin United States 54241
    289 Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin United States 53226
    290 Aurora West Allis Medical Center West Allis Wisconsin United States 53227
    291 Marshfield Medical Center - Weston Weston Wisconsin United States 54476
    292 National Cancer Center-Korea Goyang-si Gyeonggi-do Korea, Republic of 410-769
    293 Cancer Center-Metro Medical Center Bayamon Bayamon Puerto Rico 00959-5060
    294 HIMA San Pablo Oncologic Hospital Caguas Puerto Rico 00726
    295 Doctors Cancer Center Manati Puerto Rico 00674
    296 Instituto Oncologia Moderna Ponce Ponce Puerto Rico 00716
    297 San Juan Community Oncology Group San Juan Puerto Rico 00917
    298 Primary Care Physician Group San Juan Puerto Rico 00920
    299 Centro Comprensivo de Cancer de UPR San Juan Puerto Rico 00927
    300 San Juan City Hospital San Juan Puerto Rico 00936

    Sponsors and Collaborators

    • ECOG-ACRIN Cancer Research Group
    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: David S Weinberg, ECOG-ACRIN Cancer Research Group

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    ECOG-ACRIN Cancer Research Group
    ClinicalTrials.gov Identifier:
    NCT04239573
    Other Study ID Numbers:
    • EA2185
    • NCI-2019-04790
    • EA2185
    • ECOG-ACRIN-EA2185
    • EA2185
    • UG1CA189828
    First Posted:
    Jan 27, 2020
    Last Update Posted:
    Aug 12, 2022
    Last Verified:
    Dec 1, 2021
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Pancreatic Neoplasms
    Pancreatic Cyst

    Study Results

    No Results Posted as of Aug 12, 2022