The Effect of Cognitive Functions on Upper Extremity Functionality in Parkinson's Patients

• Sponsor: Pamukkale University (Other)
• Overall Status: Completed
• CT.gov ID: NCT05872646
• Collaborator: (none)
• Enrollment: 104
• Location: 1
• Arms: 2
• Actual Duration (Months): 61
• Patients Per Site Per Month: 1.7

Study Details

Study Description

Brief Summary

Parkinson's Disease (PD), first described by James Parkinson in 1817, is a progressive movement disorder that develops mainly as a result of the destruction of nigrostriatal dopaminergic neurons. The aim of our study is to determine the effect of cognitive functions on upper extremity functionality in individuals with Parkinson's Disease.

Condition or Disease	Intervention/Treatment	Phase
Parkinson; Cognitive Impairment; Upper Extremity Problem; Functional Disturbance	Diagnostic Test: clinical assessment	N/A

Detailed Description

Parkinson's Disease (PD), first described by James Parkinson in 1817, is a progressive movement disorder that develops mainly as a result of the destruction of nigrostriatal dopaminergic neurons. Involvement of nigrostriatal dopaminergic neurons is associated with the motor manifestations of the disease. The most common of these symptoms are; resting tremor, bradykinesia, rigidity and balance disorder. However, non-motor symptoms related to the involvement of nervous system structures other than the dopaminergic nigrostriatal system can be observed in PD. However, due to the predominance of motor symptoms in PD, it took many years to notice cognitive changes. Traditionally, cognitive impairments in PD have been expected to occur in the advanced stages of the disease. However, cognitive impairments in the early stages are reported in approximately 30-35% of patients. Cognitive dysfunction is defined in PD, ranging from mild impairments in certain cognitive domains to severe dementia. Cognitive impairment primarily affects executive and visuospatial functions, and memory is secondarily affected.

Executive functions are higher cognitive processes that use and modify information from many cortical sensory systems in the fore and hindbrain areas to modulate and teach behavior. The frontal cortex, especially the prefrontal cortex and its striatal connections are very important neuroanatomical regions for executive functions. The relationship between the effects of cognition and motor performance and parameters in groups such as the elderly, PD and Alzheimer's patients in which these centers are affected has been an issue that has attracted the attention of many researchers. Most of the studies have focused on the lower extremity performance of cognition. However , it has been reported that cognition has positive effects on upper extremity performance and early acquired upper extremity skills have positive effects on cognitive performance .

The aim of our study is to determine the effect of cognitive functions on upper extremity functionality in individuals with Parkinson's Disease.

Study Design

• Study Type: Interventional
• Actual Enrollment: 104 participants
• Allocation: Non-Randomized
• Intervention Model: Parallel Assignment
• Intervention Model Description: patient and age-gender matched healthy groupspatient and age-gender matched healthy groups
• Masking: None (Open Label)
• Primary Purpose: Other
• Official Title: The Effect of Cognitive Functions on Upper Extremity Functionality in Parkinson's Patients
• Actual Study Start Date: Feb 8, 2018
• Actual Primary Completion Date: Mar 10, 2023
• Actual Study Completion Date: Mar 10, 2023

Arms and Interventions

Arm	Intervention/Treatment
Experimental: patient group parkınson patient group	Diagnostic Test: clinical assessment; clinical staging; Other Names: modifiye hoehn yahr
Other: healthy group age-gender matched healthy group	Diagnostic Test: clinical assessment; clinical staging; Other Names: modifiye hoehn yahr

Outcome Measures

Primary Outcome Measures

1. Modified Hoehn Yahr Scale [1 year]

   Used for clinical staging of Parkinson's disease

2. Unified Parkinson's Disease Rating Scale [1 year]

   Used for the evaluation of clinical manifestations of Parkinson's disease

3. Parkinson's Disease Questionnaire-PDQ 39 [1 year]

   Used to assess the quality of life of Parkinson's patients

Secondary Outcome Measures

1. Stroop Test [1 year]

   measures the selective attention ability of individuals

2. Wechsler Memory Scale-Revised [1 year]

   To assess attention, learning, memory and working memory in individuals aged 16-89

3. Dexterity Questionnaire-24 [1 year]

   To assess manuel dexterity

4. Nine Hole Peg Test [1 year]

   To assess manuel dexterity

Eligibility Criteria

Criteria

• Ages Eligible for Study: 30 Years to 80 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Having a diagnosis of Parkinson's Disease.

• Not having hearing and vision problems.

• To be able to take the commands required for the manual dexterity tests.

• Agree to participate in the study.

Exclusion Criteria:

• Having undergone musculoskeletal surgery for the upper extremity.

• Having vision and hearing problems.

• Having an additional disease that may affect cognitive tests.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Pamukkale Unıversity	Denizli		Turkey	20000

Sponsors and Collaborators

• Pamukkale University

Investigators

• Study Chair: DUDU ŞIMŞEK, PhD student

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Dudu ŞİMŞEK, MSc Physiotherapist, Pamukkale University
• ClinicalTrials.gov Identifier: NCT05872646
• Other Study ID Numbers: PamukkaleU-sımsek-parkınson-01
• First Posted: May 24, 2023
• Last Update Posted: May 24, 2023
• Last Verified: May 1, 2023

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by Dudu ŞİMŞEK, MSc Physiotherapist, Pamukkale University: Parkinson; Cognitive function; Upper extremity
• Additional relevant MeSH terms: Parkinson Disease

Study Results

No Results Posted as of May 24, 2023