Neurophysiological Characteristics of Subthalamic Deep-brain Stimulation (STN-DBS)
Study Details
Study Description
Brief Summary
The intraoperative neuroelectrophysiological signals were collected from patients undergoing STN-DBS under general anesthesia in the Neurosurgery Department of Wuhan union Hospital, and their preoperative conditions and postoperative efficacy will be evaluated.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
The intraoperative neuroelectrophysiological signals were collected from patients undergoing STN-DBS under general anesthesia in the Neurosurgery Department of Wuhan union Hospital, and their preoperative conditions and postoperative efficacy will be evaluated. The intraoperative neuroelectrophysiological signals would be analyzed.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Parkinson's disease or dystonia patients Patients with Parkinson's disease or dystonia and underwent STN DBS under general anesthesia in neurosurgery department |
Other: No intervention used
No intervention used
|
Outcome Measures
Primary Outcome Measures
- Unified Parkinson's Disease Rating Scale (UPDRS) [Two years postoperatively]
UPDRS has four parts: part I (nonmotor experiences of daily living, total score=16); part II (patient motor experience of daily living, total score=52); part III (clinician motor examination, total score=56); part IV (complications, total score=23). The total score of all the four parts is147. Higher scores means a worse outcome.
- Burke Fahn Marsden's Dystonia Rating Scales(BFMDRS) [Two years postoperatively]
BFMDRS has two parts: BFMDRS movement part (BFMDRS-M) and BFMDRS disability part (BFMDRS-D). The total score of BFMDRS-M is 120 and the total score of BFMDRS-D is 30. Higher scores means a worse outcome.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients underwentSTN-DBS in neurosurgery department of Wuhan Union Hospital.
-
Patients with Parkinson's disease or dystonia.
Exclusion Criteria:
1.Patients without enough follow-up length.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Wuhan Union Hospital, China
- Huazhong University of Science and Technology
Investigators
- Principal Investigator: Fu Peng, PHD, Neurosurgery department of Wuhan Union Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
- Tsai ST, Kuo CC, Chen TY, Chen SY. Neurophysiological comparisons of subthalamic deep-brain stimulation for Parkinson's disease between patients receiving general and local anesthesia. Ci Ji Yi Xue Za Zhi. 2016 Apr-Jun;28(2):63-67. doi: 10.1016/j.tcmj.2016.02.003. Epub 2016 Apr 10.
- Yamada K, Goto S, Kuratsu J, Matsuzaki K, Tamura T, Nagahiro S, Murase N, Shimazu H, Kaji R. Stereotactic surgery for subthalamic nucleus stimulation under general anesthesia: a retrospective evaluation of Japanese patients with Parkinson's disease. Parkinsonism Relat Disord. 2007 Mar;13(2):101-7. Epub 2006 Oct 19.
- NS20201230