Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation
Study Details
Study Description
Brief Summary
The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes. Using neurophysiology data recorded during DBS surgeries and post-implantation, the research intends to identify biomarkers in order to optimize electrode placement, enhance programming, and ultimately minimize DBS-related cognitive side effects.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: Determination of DLPFC neurophysiology biomarkers of DBS associated cognitive impairment Neurophysiology recordings will be performed from dorsolateral prefrontal cortex (DLPFC) during deep brain stimulation surgery, with and without STN or GPI stimulation, at rest and during a working memory task. |
Device: Neural recordings and stimulation
Neural activities from the dorsolateral prefrontal cortex and implanted DBS generator will be recorded, during resting and working memory tasks, and with the DBS target turned on and off.
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Experimental: Neurophysiology biomarkers of DBS mediated cognitive impairment following chronic stimulation Neurophysiology recordings will be performed from subthalamic nucleus (STN) or globus pallidus internus (GPI) with stimulation on and off, at rest and during a working memory task, in patients who have previously been implanted with DBS and have implantable pulse generators capable of recording local field potentials. |
Device: Neural recordings and stimulation
Neural activities from the dorsolateral prefrontal cortex and implanted DBS generator will be recorded, during resting and working memory tasks, and with the DBS target turned on and off.
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Outcome Measures
Primary Outcome Measures
- Determination of DLPFC beta power a biomarker of DBS associated cognitive impairment in the acute stimulation setting [Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours]
Working memory tasked will be conducted during surgery, and local field potentials (LFPs) will be recorded from the DLPFC both at rest and during task execution, under two conditions: with and without stimulation.
- Determination of STN local field potential biomarkers of DBS mediated cognitive impairment following chronic stimulation [1 hour]
Local field potentials will be recorded from subthalamic nucleus or globus pallidus internus in patients with an existing DBS system with implantable pulse generator capable of recording local field potentials. Recordings will be performed at rest and during a working memory task, with DBS on and off.
Eligibility Criteria
Criteria
Inclusion Criteria:
• Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center (Arm 1)
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Active deep brain stimulation system with implantable pulse generator capable of recording local field potentials (Arm 2)
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Diagnosis of Parkinson's disease as determined by a movement disorders specialist neurologist
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Age at least 18
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Able to participate in intraoperative testing
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English speaking
Exclusion Criteria:
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Age less than 18
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Not able to participate in intraoperative testing (ex unable to comprehend instructions or follow directions)
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Vanderbilt University Medical Center | Nashville | Tennessee | United States | 37232 |
Sponsors and Collaborators
- Vanderbilt University Medical Center
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 230539