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Effectiveness of Oculomotor Training in Parkinson's Disease

Sponsor
The Hong Kong Polytechnic University (Other)
Overall Status
Enrolling by invitation
CT.gov ID
NCT04560504
Collaborator
University of California, Berkeley (Other), Deakin University (Other), Chinese University of Hong Kong (Other), Hospital Authority, Hong Kong (Other)
90
Enrollment
1
Location
2
Arms
26.9
Anticipated Duration (Months)
3.3
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Parkinson's disease (PD) is a common neurodegenerative disorder which is characterized by both motor and non-motor symptoms and usually affects people aged 50 years or above. Many studies showed eye movement deficits and visual changes in patients with PD.

Previous studies have also indicated that clinical eye movement training could enhance the functional performance of patients with various eye movement problems resulting from ocular and neurodegenerative diseases.

In this study, we will investigate the effectiveness of eye movement training on dynamic vision and functional performance in PD patients with oculomotor deficits.

Condition or Disease Intervention/Treatment Phase
  • Other: Control Group
  • Other: Oculomotor Training Group
 N/A

Study Design

Study Type:
Interventional
Anticipated Enrollment :
90 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Double (Participant, Outcomes Assessor)
Primary Purpose:
Other
Official Title:
Oculomotor Deficits in Parkinson's Disease: Enhancing Eye Movement Performance and Dynamic Visual Acuity With Oculomotor Training Using a Pilot Randomized Clinical Trial Design
Actual Study Start Date :
Sep 3, 2020
Anticipated Primary Completion Date :
Aug 31, 2022
Anticipated Study Completion Date :
Dec 1, 2022

Arms and Interventions

Arm Intervention/Treatment
Placebo Comparator: Control Group

Receive 10 sessions of 45-minute (3 sessions per week) in-office leisure activities e.g. simple non-action computer games or board games (e.g. card and chess games) and 10-20 minutes of video watching at home

Other: Control Group
Leisure activities
Active Comparator: Intervention Group

Receive 10 sessions of 45-minute office training (3 sessions per week) and 10-20 minute home training (3 sessions per week) of eye movement training

Other: Oculomotor Training Group
Eye movement training

Outcome Measures

Primary Outcome Measures

  1. Smooth Vergence eye movements [Change from baseline at week 4 and change from baseline at week 12]

    Smooth vergence eye movement is measured using a head-mounted eye tracking while fixating at an approaching target moving at different speeds

Secondary Outcome Measures

  1. Oculomotor characteristics [Change from baseline at week 4 and change from baseline at week 12]

    With the use of eye tracking device, eye movement behavior of participants can be measured and analysed while performing the following tasks. Fixation task - Fixate at stationary target presented on a monitor Saccade task - Follow and fixate at a random jumping target presented on a monitor Pursuit task - Follow accurately and steadily on a smooth moving target presented on a monitor Jump Vergence task - Follow and fixate a jumping target presented in the anterior-posterior plane (jumping from 'far to near' or 'near to far')

  2. Sentence reading performance [Change from baseline at week 4 and change from baseline at week 12]

    To evaluate the effectiveness of the interventions on sentence reading using MNREAD charts in Chinese. These charts developed in our laboratory are used to measure the effectiveness of sentence reading in terms of reading speed and critical print size.

  3. Passage reading performance [Change from baseline at week 4 and change from baseline at week 12]

    To evaluate the effectiveness of the interventions on passage reading using International Reading speed Test (IReST). IReST is used to evaluate the effectiveness of passage reading performance by measuring the reading speed.

Eligibility Criteria

Criteria

Ages Eligible for Study:
40 Years to 70 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  • Parkinson's Disease diagnosed by a neurologist or geriatrician with the range of Stage

1 to 4 (Hoehn and Yahr Classification)

  • Able to speak and comprehend Cantonese dialect

  • Able to travel independently

Exclusion Criteria:

  • Any congenital eye problem (e.g. congenital strabismus or amblyopia in either eye) or any manifest eye diseases (e.g. macular degeneration, glaucoma, etc)

  • Severe medical problems (e.g. stroke)

  • Cognitive impairment (e.g. dementia)

  • Presence of any psychiatric or neurological diseases (apart from Parkinson's disease) or receiving of any psychoactive pharmacological treatment

  • Receiving any medication that is known to affect eye movement and cognitive function

  • Previous formal vision rehabilitation or oculomotor intervention

Contacts and Locations

Locations

Site City State Country Postal Code
1 Allen MY Cheong Hong Kong Hong Kong

Sponsors and Collaborators

  • The Hong Kong Polytechnic University
  • University of California, Berkeley
  • Deakin University
  • Chinese University of Hong Kong
  • Hospital Authority, Hong Kong

Investigators

  • Principal Investigator: Allen Ming Yan Cheong, PhD, The Hong Kong Polytechnic University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Allen MY Cheong, Associate Professor, The Hong Kong Polytechnic University
ClinicalTrials.gov Identifier:
NCT04560504
Other Study ID Numbers:
  • 15102717
First Posted:
Sep 23, 2020
Last Update Posted:
Apr 22, 2022
Last Verified:
Apr 1, 2022
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Allen MY Cheong, Associate Professor, The Hong Kong Polytechnic University
Parkinson Disease
Oculomotor deficit
Oculomotor training
Dynamic vision
Additional relevant MeSH terms:
Parkinson Disease

Study Results

No Results Posted as of Apr 22, 2022