The Efficacy of a Remote Cognitive Remediation Therapy (CRT) Program on Parkinson's Disease
Study Details
Study Description
Brief Summary
Purpose/Goal: To determine if a remote computerized cognitive remediation program (CRT) can stabilize or improve cognitive functioning in a group of patients from the AHCC with Parkinson's disease (PD) after three months of intervention.
Hypothesis: Patients with PD who present with current cognitive deficits will show improvement in such deficits after three months of participation in a remotely supervised structured Cognitive Remediation Therapy Program (CRT) compared to control subjects with PD who receive treatment as usual.
Research design: Pilot study. Prospective randomized treatment and control comparison pre-post study.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Parkinson's Disease Patients receiving Cognitive Remediation Therapy Parkinson's Disease Subjects will undergo 10 weeks of Brain HQ training, 2 times a week an hour at a time. Also patients pre- and post-intervention RBANS and PDQ-39 scores. |
Other: Cognitive Remediation Therapy Program (BrainHQ)
Brain HQ games involving training cognitive abilities like memory and attention, made up of adapting tasks or creating our own.
|
| No Intervention: Parkinson's Disease Patients not receiving Cognitive Remediation Therapy Parkinson's Disease Subjects will receive no intervention, but still undergo pre- and post-intervention RBANS and PDQ-39 scores. |
Outcome Measures
Primary Outcome Measures
- The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Pre-Intervention [Initially, before any intervention/start of study.]
A brief, individually administered test measuring attention, language, visuospatial/constructional abilities, and immediate and delayed memory.
- The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Post-Intervention [10 weeks after intervention/completion of the study.]
A brief, individually administered test measuring attention, language, visuospatial/constructional abilities, and immediate and delayed memory.
- Parkinson's Disease Questionnaire (PDQ-39) Pre-Intervention [Initially, before any intervention/start of study.]
A test that assesses how often people affected by Parkinson's experience difficulties across 8 dimensions of daily living including relationships, social situations and communication.
- Parkinson's Disease Questionnaire (PDQ-39) Post-Intervention [10 weeks after intervention/completion of the study.]
A test that assesses how often people affected by Parkinson's experience difficulties across 8 dimensions of daily living including relationships, social situations and communication.
- Montreal Cognitive Assessment (MOCA) Pre-Intervention Screening [Initially, before any intervention/start of study.]
A rapid screening instrument for mild cognitive dysfunction. It assesses different cognitive domains: attention and concentration, executive functions, memory, language, visuoconstructional skills, conceptual thinking, calculations, and orientation.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Subjects must be currently enrolled in the Rock Steady Boxing Program at the Adele Smithers Parkinson's Disease Center.
-
Subjects must be between 40 and 85 years old (including both ages) at the time of study screening.
-
Subjects must have a diagnosis of Parkinson's disease by a physician.
-
Subjects must have a MOCA score of 20 or above.
-
Subjects must demonstrate adequate decisional capacity, in the judgment of the consenting study staff member, to make a choice about participating in this research study.
-
Subjects must have been clinically stable for 2 weeks prior to consent; in the judgment of the Investigator.
-
Subjects must have the visual, auditory, and motor capacity to use the intervention in the judgment of the Principal Investigator.
-
Subjects must be technologically capable of utilizing a computer and navigating through the programs.
-
Subjects must be mechanically capable of utilizing a computer and computer mouse.
Exclusion Criteria:
-
Subjects should not be participating in a concurrent research study or other interventional clinical trial 30 days prior to consenting.
-
Subjects should not have a history of mental retardation or pervasive developmental disorder; or other co-morbid neurological disorder (e.g., epilepsy.)
-
Subject is unable to physically use a computer or a computer mouse.
-
Subject is unable to or refuses to give consent.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | New York Institute of Technology | Old Westbury | New York | United States | 11568 |
Sponsors and Collaborators
- New York Institute of Technology
Investigators
None specified.Study Documents (Full-Text)
More Information
Publications
- Díez-Cirarda M, Ibarretxe-Bilbao N, Peña J, Ojeda N. Efficacy of cognitive rehabilitation in Parkinson's disease. Neural Regen Res. 2018 Feb;13(2):226-227. doi: 10.4103/1673-5374.226390.
- Díez-Cirarda M, Ojeda N, Peña J, Cabrera-Zubizarreta A, Lucas-Jiménez O, Gómez-Esteban JC, Gómez-Beldarrain MÁ, Ibarretxe-Bilbao N. Increased brain connectivity and activation after cognitive rehabilitation in Parkinson's disease: a randomized controlled trial. Brain Imaging Behav. 2017 Dec;11(6):1640-1651. doi: 10.1007/s11682-016-9639-x.
- Gough N, Brkan L, Subramaniam P, Chiuccariello L, De Petrillo A, Mulsant BH, Bowie CR, Rajji TK. Feasibility of remotely supervised transcranial direct current stimulation and cognitive remediation: A systematic review. PLoS One. 2020 Feb 24;15(2):e0223029. doi: 10.1371/journal.pone.0223029. eCollection 2020.
- Milman U, Atias H, Weiss A, Mirelman A, Hausdorff JM. Can cognitive remediation improve mobility in patients with Parkinson's disease? Findings from a 12 week pilot study. J Parkinsons Dis. 2014;4(1):37-44. doi: 10.3233/JPD-130321.
- Petersen RC, Caracciolo B, Brayne C, Gauthier S, Jelic V, Fratiglioni L. Mild cognitive impairment: a concept in evolution. J Intern Med. 2014 Mar;275(3):214-28. doi: 10.1111/joim.12190.
- BHS-1660