EMOPHYSIO: Electrophysiological Activity of the Subthalamic Nucleus During the Processing of Emotional and Motivational Information
Study Details
Study Description
Brief Summary
The role of the basal ganglia in the processing of information with emotional or motivational content has been demonstrated by several lesion and functional imaging studies in humans and animals. Deep brain stimulation surgery provides an opportunity to study these structures in humans in electrophysiological terms. The aim of this study is to investigate modifications in the electrophysiological activity of the subthalamic nucleus (STN) during the perception of auditory and visual stimuli with emotional or motivational connotations in patients with Parkinson's disease who have just undergone implantation of a deep brain stimulator in the STN.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Other: neurostimulation
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Other: Measure of the electrophysiological activity of the subthalamic nucleus
Local field recording of the subthalamic nucleus by mean of externalized electrodes in the immediate postoperative periode.
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Outcome Measures
Primary Outcome Measures
- Electrophysiological activity of the subthalamic nucleus [5 days]
Electrophysiological activity of the subthalamic nucleus will be measured during the perception of auditory and visual stimuli with emotional or motivational connotations in patients with Parkinson disease who have just undergone implatation of a deep brain stimulator in the subthalamic nucleus
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patient with Parkinson's disease selected for deep brain stimulation (DBS) of the subthalamic nucleus (STN) in accordance with the criteria established by Welter and colleagues (Welter et al., 2002);
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Aged 18 years or above;
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Written informed consent from the patient.
Exclusion Criteria:
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Patient under a legal incapacity or with limited legal capacity;
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Patient who has perioperative complications or postoperative confusion;
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Patient displaying cognitive disturbances involving the early stages of speech processing (on the basis of an audiogram systematically conducted prior to surgery) ;
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Patient displaying cognitive disturbances involving the early stages of face processing (on the basis of the Benton Facial Recognition Test (Benton, Hamsher, Varney, & Spreen, 1983) systematically administered prior to surgery);
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Patient incapable of understanding the information given about the study, performing the tasks or providing informed consent.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | CHU Rennes | Rennes | France | 35000 |
Sponsors and Collaborators
- Rennes University Hospital
Investigators
- Principal Investigator: Marc Verin, MD, PhD, Rennes University Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2011-A00392-39