Clinical, Molecular and Metabolic Characteristics of Parkinson's Disease (PD) Patients With Parkin Mutation

• Sponsor: Groupe Hospitalier Pitie-Salpetriere (Other)
• Overall Status: Unknown status
• CT.gov ID: NCT00169364
• Collaborator: University Hospital, Tours (Other)
• Enrollment: 50
• Location: 1

Study Details

Study Description

Brief Summary

Parkinson's disease is a frequent neurodegenerative disorder. Genetic forms of the disease have been recently identified. The monogenic form due to parkin mutation is responsible for many familial cases and sporadic forms. However, the relationship between the mutation and the genotype of patients is not fully established. The aim of this study is to compare clinical, metabolic and neuropsychological characteristics obtained in patients with parkin mutation with those of patients without parkin mutation.

Condition or Disease	Intervention/Treatment	Phase
Parkinson's Disease	Device: positron emission tomography	N/A

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 50 participants
• Allocation: Non-Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Diagnostic
• Official Title: Comparison of Clinical, Molecular and Metabolic Characteristics of PD Patients With and Without Parkin Mutation
• Study Start Date: May 1, 2002

Outcome Measures

Primary Outcome Measures

1. Parkin mutation []

2. Motor disability []

3. Neuropsychological evaluation []

4. Psychiatric evaluation []

Secondary Outcome Measures

1. Positron emission tomography []

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 80 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Juvenile Parkinson's disease (< 45 years)

• Parkin mutation

• Normal brain magnetic resonance imaging (MRI)

Exclusion Criteria:

• Contraindication to brain MRI

• Women without effective contraception

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Centre d'Investigation Clinique-Hôpital Pitié-Salpetriere	Paris		France

Sponsors and Collaborators

• Groupe Hospitalier Pitie-Salpetriere
• University Hospital, Tours

Investigators

• Study Director: Alexis Brice, MD, PhD, Groupe Hospitalier Pitié-Salpêtrière

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT00169364
• Other Study ID Numbers: P011104
• First Posted: Sep 15, 2005
• Last Update Posted: Aug 29, 2007
• Last Verified: Sep 1, 2005

• Keywords provided by , ,: Parkinson's disease; parkin mutation; Juvenile parkinson's disease; positron emission tomography
• Additional relevant MeSH terms: Parkinson Disease

Study Results

No Results Posted as of Aug 29, 2007