EEG-HR: Localizing the Epileptogenic Zone With High Resolution Electroencephalography
Study Details
Study Description
Brief Summary
Multicenter prospective study comparing the diagnosis value of high-resolution EEG and depth-EEG to localize the epileptogenic zone in drug resistant partial epilepsies.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: high resolution EEG
|
Device: High Resolution EEG
High Resolution EEG
Other Names:
|
| Active Comparator: Stereo Electroencephalography
|
Device: Stereo-electroencephalography
SEEG
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Sensitivity and specificity of electrical source localization of inter-ictal and ictal discharges using high-Resolution EEG for localizing the epileptogenic zone (the stereo-electroencephalography will be the reference method) [3 years]
results of electrical sources localization of inter-ictal and ictal discharges are compared to the epileptogenic zone defined by SEEG
Secondary Outcome Measures
- inter-observer reliability of electrical source localization of inter-ictal and ictal discharges for localizing the epileptogenic zone. [3 years]
sources localization of inter-ictal and ictal discharges will be interpreted by two independant epileptologists, blinded to the results of stereo-EEG.
- sensitivity and specificity of high resolution EEG and electrical source imaging for surgical decision [3 years]
decision of surgery and the limits of the cortectomy established with electrical source imaging will be compared to the decision of surgery and the limits of the cortectomy established with Stereo-electroencephalography.
Eligibility Criteria
Criteria
Inclusion Criteria:
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medically intractable patial epilepsy confirmed by video-EEG recordings of epileptic seizures.
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Depth EEG (Stereo-EEG) required to delineate the epileptogenic zone and define the surgical procedure.
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full informed consent of the patient (or of his/ her legal representative)
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15 year or older patient
Exclusion Criteria:
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contraindication to cortectomy
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contraindication to depth-EEG
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indication of epilepsy surgery without depth-EEG monitoring
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high grade glioma, arterio-veinous malformations
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pregnancy
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history of severe cardio-vascular event (coronaropathy, stroke)
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University Hospital of Marseille | Marseille | France | 13000 | |
| 2 | Central Hospital | Nancy | France | 54000 |
Sponsors and Collaborators
- Central Hospital, Nancy, France
- University Hospital, Marseille
- CHU de Reims
- Centre National de la Recherche Scientifique, France
- Institut National de la Santé Et de la Recherche Médicale, France
Investigators
- Principal Investigator: Louis Maillard, MD, PhD, Central Hospital, Nancy, France
Study Documents (Full-Text)
None provided.More Information
Publications
- Koessler L, Benar C, Maillard L, Badier JM, Vignal JP, Bartolomei F, Chauvel P, Gavaret M. Source localization of ictal epileptic activity investigated by high resolution EEG and validated by SEEG. Neuroimage. 2010 Jun;51(2):642-53. doi: 10.1016/j.neuroimage.2010.02.067. Epub 2010 Mar 4.
- Maillard L, Koessler L, Colnat-Coulbois S, Vignal JP, Louis-Dorr V, Marie PY, Vespignani H. Combined SEEG and source localisation study of temporal lobe schizencephaly and polymicrogyria. Clin Neurophysiol. 2009 Sep;120(9):1628-36. doi: 10.1016/j.clinph.2009.06.022. Epub 2009 Jul 24.
- 2009-A00574-53