Feasibility Study of the Execution of an Efficacy Trial in the Nursing Home Setting

Sponsor

Healthpoint (Industry)

Overall Status

Withdrawn

CT.gov ID

NCT00714519

Collaborator

(none)

Enrollment

Arms

Duration (Months)

Study Details

Study Description

Brief Summary

This study will assess if a clinical trial regarding healing of partial thickness wounds can be executed in nursing homes.

Condition or Disease	Intervention/Treatment	Phase
Partial Thickness Wounds	Drug: Xenaderm® Ointment Drug: Placebo Comparator	Phase 2

Detailed Description

This study will test the efficacy of Xenaderm® vs. vehicle on the healing of partial thickness wounds caused by pressure, moisture and friction.

Study Design

Study Type:

Interventional

Actual Enrollment :

0 participants

Allocation:

Randomized

Intervention Model:

Single Group Assignment

Masking:

Triple (Care Provider, Investigator, Outcomes Assessor)

Primary Purpose:

Treatment

Official Title:

A Phase II Feasibility Study of Xenaderm® Ointment Exploring Design Issues for Phase III Efficacy in Partial-Thickness Wounds

Study Start Date :

Jul 1, 2008

Actual Primary Completion Date :

Oct 1, 2008

Actual Study Completion Date :

Oct 1, 2008

Arms and Interventions

Arm	Intervention/Treatment
Experimental: 1	Drug: Xenaderm® Ointment Topical, BID or as needed Other Names: Placebo Comparator
Placebo Comparator: 2	Drug: Placebo Comparator Topical, BID or as needed Other Names: Xenaderm® Ointment

Arm

Intervention/Treatment

Experimental: 1

Drug: Xenaderm® Ointment

Topical, BID or as needed

Other Names:

Placebo Comparator

Placebo Comparator: 2

Drug: Placebo Comparator

Topical, BID or as needed

Other Names:

Xenaderm® Ointment

Outcome Measures

Primary Outcome Measures

Complete Wound Closure [21 days]

Secondary Outcome Measures

Adverse Events [21 days]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Provide written informed consent, which consists of reading, signing and dating the informed consent document after the Investigator, sub-Investigator or other designated study staff member has explained the study procedures, risks, and contact information. If the subject is unable to read or sign the informed consent, or unable to comprehend the information provided in the consent process, a legal guardian, decision making proxy, or next of kin must provide written consent, and if possible, subject must verbally assent to receiving an experimental treatment for their wound.
Are at least 18 years of age.
Are expected to remain in the Nursing Home for the duration of the study (22 days).
Have one or more partial-thickness wounds (including wounds with excoriation, erosion or denuded skin, or ulceration to subcutaneous fat, but with no fascia, muscle, tendon or bone visible) on the trunk or proximal extremity (arm above the elbow, leg above the knee) which

have been present for at least 2 days but less than 6 weeks;
measure greater than or equal to 2 and less than or equal to40 cm2 in total denuded area; and,
are connected by areas of erythema (for multiple wounds).

Are capable of maintaining an adequate nutritional intake during the study.
Are in an acceptable state of health and nutrition with pre-albumin levels of greater than or equal to 15 mg/dl (0.015g/l), serum albumin greater than or equal to 3.0 g/dl (30g/l), alkaline phosphatase greater than or equal to the lower limit of normal, and have no abnormal laboratory values that, in the opinion of the Medical Supervisor, place the subject at risk for the study.

Exclusion Criteria:

Have more than 64 cm2 of total denuded wound area, including target and non-target wounds.
Have a full-thickness wound within 4 cm of any target wound.
Have clinical evidence of bacterial or fungal infection of the target wound.
Have target wound(s) that involves tunneling, sinus tracks, shear injury, arterial occlusive disease or bony prominence or joint with the exception that target wounds may be over dorsal spinous processes, coccyx, ischial tuberosities or sacroiliac joints (but may not be full thickness).
Are moribund, or has a severe burn, immunodeficiency disorder, hematologic disorder, metastatic malignancy or uncontrolled diabetes mellitus.
Are known to have acrodermatitis enteropathica (zinc deficiency).
Are being treated with systemic steroids, immunosuppressive agents, radiation or chemotherapy.
Have been treated with enzymatic debridement to the target wound(s) within 2 days prior to enrollment.
Have a known sensitivity to ingredients of Xenaderm Ointment.
Are using or have used another investigational agent (not including devices such as hearing aids, pace makers, etc.) within 30 days prior to Visit 1.