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Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy

Sponsor
University Hospital, Basel, Switzerland (Other)
Overall Status
Completed
CT.gov ID
NCT00410111
Collaborator
(none)
23
Enrollment
1
Location
5.9
Duration (Months)
3.9
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown. We will investigate whether patients who develop this condition have different patterns of cerebrovascular reactivity and whether it is possible to predict the development of septic encephalopathy from early measurements of cerebral perfusion or from the EEG. We will specifically test the hypotheses that septic encephalopathy may not be predicted by changes in the EEG, and that cerebrovascular autoregulation is not dysfunctional in septic encephalopathy.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    23 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    A Pilotstudy on Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy
    Study Start Date :
    Jan 1, 2007
    Actual Study Completion Date :
    Jul 1, 2007

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      16 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:

      • Sepsis

      • Admission to ICU

      Exclusion Criteria:

      • CNS infection

      • History of cerebrovascular disease

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Operative Intensivbehandlung, University of Basel Hospital Basel Switzerland 4031

      Sponsors and Collaborators

      • University Hospital, Basel, Switzerland

      Investigators

      • Principal Investigator: Luzius A Steiner, MD PhD, Department of Anesthesia, University of Basel Hospital, Basel, Switzerland

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00410111
      Other Study ID Numbers:
      • EKBB 226/06
      First Posted:
      Dec 12, 2006
      Last Update Posted:
      Oct 16, 2008
      Last Verified:
      Oct 1, 2008
      Keywords provided by , ,
      sepsis
      encephalopathy
      cerebral perfusion
      electroencephalogram
      Additional relevant MeSH terms:
      Brain Diseases
      Sepsis-Associated Encephalopathy

      Study Results

      No Results Posted as of Oct 16, 2008