Pathology of Hepatitis c Nephropathy
Study Details
Study Description
Brief Summary
Hepatitis c associated glomerulonephritis is an immune complex disease that occurs in 21% of patients who have HCV infection.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Hepatitis C virus infection is a major public health problem with an estimated global prevalence of 3% and an estimated 5-20% of infected patients will develop liver cirrhosis .The Prevalence of Hepatitis C infection in end stage renal disease is greater than in the general population especially in those on hemodialysis which reflects nosocomial transmission of the disease in the hemodialysis environment.
Hepatitis C associated glomerulonephritis is an immune complex disease that occurs in 21% of patients who have HCV infection. It most commonly presents as membranoproliferative and mixed cryoglobulinemia It characterized by an indolent course in one third of patients , remission in another third and relapsing course in the remaining patients with potential progression to advanced chronic kidney disease.
mechanism of injury : Chronic Hepatitis C is primarily associated with type II cryoglobulinemia , in which the primary mechanism of injury is vasculitis that occurs via immune complex deposition.
hepatitis C virus related glomerular disease :
Type I membranoproliferative was the most common finding associated with mixed cryoglobulinemia but other forms of glomerulonephritis were associated with Hepatitis c like mesangial glomerulonephritis,focal and segmental glomerulonephritis,minimal change nephropathy,membranous nephropathy , Fibrillary glomerulonephritis,immunotactoid glomerulopathy,IgA nephropathy, vasculitic renal involvement ,poly arteritis nodosa and interstitial nephritis .
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| study group patients with hepatitis c nephropathy detected by lab and renal biopsy |
Diagnostic Test: renal biopsy
needle biopsy will be taken from the kidney tissue then, diagnosed
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Outcome Measures
Primary Outcome Measures
- prevalence of histopathological pattern in patients with hepatitis C virus [one year]
prevalence of histopathological pattern in patients with hepatitis C virus
Eligibility Criteria
Criteria
Inclusion Criteria:
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it will be conducted on chronic hepatitis C patients with chronic kidney disease .
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The participants will be classified according to their estimated GFR by modified MDRD equation and
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they will be recruited from the renal unit of internal medicine, Assiut University Hospitals and assiut hepatitis viruses unit-ministry of health, Egypt.
Exclusion Criteria:
Patients will be excluded if the underlying causes of CRF are as follows:
chronic pyelonephritis,obstructive uropathy,Polycystic kidney disease,Patients with ESRD on regular hemodialysis,patients with advanced liver cirrhosis,hepatocellular carcinoma,Patients on steroids or immunosuppressive drugs and Solitary kidney.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Assuit University | Assuit | Egypt | 7115115 |
Sponsors and Collaborators
- Assiut University
Investigators
- Study Director: Mohamed Tohammy, PhD, Faculty of medicine , internal medicine ,Assuit university
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- DHPP