Pattern of Microbial Infection in AECOPD Patients and Its Sensitivity to Antibiotics
Study Details
Study Description
Brief Summary
Measurement of bacterial species causing AECOPD and their Sensitivity pattern to antibiotics.
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Detailed Description
Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality worldwide.
Acute exacerbation is a common problem during the natural course of COPD, which is characterized by an increase in the patient's daily symptoms of dyspnea, cough, and/or sputum beyond normal day-to-day variability and severe enough to require an additional therapy.
The most common cause of acute exacerbations of COPD (AECOPD) is an infection of the tracheobronchial tree and air pollution. As many as one-third of AECOPD causes are never identified. The microbial aetiology of AECOPD includes bacteria and viruses with more than 50% of cases being caused by bacterial infection.
The bacterial etiologies of AECOPD keep changing from time to time and the choice of antimicrobial depends upon on local prevalence of bacterial etiologies and their resistance pattern.
Antibiotics are the main form of treatment for AECOPD which are often initiated empirically based on healthcare provider's previous experiences , which often lead to the inappropriate use of antibiotics , thereby contributing to Antimicrobial Resistance.
Early diagnosis and knowledge of the predominant bacterial etiologies and antimicrobial resistance patterns will also help to correct treatment protocol for the management of AECOPD.
Study Design
Outcome Measures
Primary Outcome Measures
- Pattern of Microbial infection based on sputum culture results. [Baseline]
Identification of causative Microbial organisms of AECOPD based on results of sputum culture.
- Pattern of antimicrobial sensitivities based on sputum culture results. [Baseline]
Identification of antimicrobial sensitivities and resistance patterns in this population based on results of sputum culture.
Secondary Outcome Measures
- Hospital length of stay [Baseline]
Exploring the relationship between the different causative organisms of AECOPD and the hospital length of stay.
Eligibility Criteria
Criteria
Inclusion Criteria:
Patients who are at least 18 years of age and at maximum of 80 years of both genders.
Confirmed COPD by spirometry. AECOPD patients (increase of grade of dyspnea , purulence and amount of sputum ) admitted in chest department or ICU .
Positive sputum culture
Exclusion Criteria:
Patients less than 18 years old. Patients with any associated pulmonary co-morbidities
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Assiut University
Investigators
- Study Director: Khaled H. Ahmed, Professor, Assuit U
- Study Director: Samiaa H Sadek, Professor, Assuit U
Study Documents (Full-Text)
None provided.More Information
Publications
- Momanyi L, Opanga S, Nyamu D, Oluka M, Kurdi A, Godman B. Antibiotic Prescribing Patterns at a Leading Referral Hospital in Kenya: A Point Prevalence Survey. J Res Pharm Pract. 2019 Oct 16;8(3):149-154. doi: 10.4103/jrpp.JRPP_18_68. eCollection 2019 Jul-Sep.
- Rodriguez-Roisin R. Toward a consensus definition for COPD exacerbations. Chest. 2000 May;117(5 Suppl 2):398S-401S. doi: 10.1378/chest.117.5_suppl_2.398s.
- Sethi S, Murphy TF. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med. 2008 Nov 27;359(22):2355-65. doi: 10.1056/NEJMra0800353. No abstract available.
- Slone DE, Ganjam VK, Purohit RC, Ravis WR. Cortisol (hydrocortisone) disappearance rate and pathophysiologic changes after bilateral adrenalectomy in equids. Am J Vet Res. 1983 Feb;44(2):276-9.
- Venkatesan P. GOLD report: 2022 update. Lancet Respir Med. 2022 Feb;10(2):e20. doi: 10.1016/S2213-2600(21)00561-0. Epub 2021 Dec 20. No abstract available.
- Bacteriology in AECOPD