PeKiT: Pediatric Kidney Transplant
Study Details
Study Description
Brief Summary
End-stage renal disease (ESRD) is a rare disease in children. Renal transplantation (RT) is the treatment of choice for ESRD in the pediatric population. In France, around 100 pediatric kidney transplants are performed each year. The aim was to evaluate the surgical management of TR and the long-term results.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
|
Detailed Description
End-stage renal disease (ESRD) is a rare pathology in children, whose gold standard treatment is a kidney transplant. In France, around 100 pediatric kidney transplants are performed every year.
Although the first adult kidney transplants were performed in 1954, pediatric renal transplantation was considered unsafe compared with dialysis, which was preferred. In the 1980s, improved graft selection, optimized pre-transplant management and a better understanding of the immune system led to the development of pediatric kidney transplantation.
Despite considerable progress, graft survival in these long-lived patients remains a major challenge.
The aim of this study is to evaluate surgical practices in the four French pediatric transplant centers, and to define risk factors for surgical complications.
Study Design
Outcome Measures
Primary Outcome Measures
- Surgical outcomes [10 years]
To assess surgical outcome in pediatric renal transplantation in terms of per operative complications (ClassIntra classification) post operative complications (Clavien Dindo) early < 30 days and late > 30 days
Secondary Outcome Measures
- Surgical complications [10 years]
Evaluate the surgical morbidity of renal transplantation
- Graft Survival [10 years]
Evaluate graft survival at 1, 5 and 10 years post transplantation
- Return to dialysis [10 years]
Evaluation of the need to return to dialysis after transplantation : causes and reasons
- Retransplantation [10 years]
Evaluation the number of patient undegoing another transplantation
- Death [10 years]
Evaluation of the morbidity of this population
Eligibility Criteria
Criteria
Inclusion Criteria:
- All pediatric patients who underwent renal transplantation in one of the 4 centers
Exclusion Criteria:
- Multi organ transplant
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | l'hôpital mère-enfant de Lyon | Bron | France | ||
| 2 | l'hôpital mère enfant de Nantes | Nantes | France | ||
| 3 | l'hôpital Robert Debré | Paris | France | 75019 | |
| 4 | l'hôpital Necker Enfants malades. | Paris | France |
Sponsors and Collaborators
- Imagine Institute
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- HJ-21-PeKiT