Penicillin Allergy Testing and Resensitization Rate
Study Details
Study Description
Brief Summary
Penicillin is one of the earliest discovered antibiotics and a drug of choice for several infections. Up to 10 to 20% of all patients in clinical trial are labeled as penicillin allergic. Most of these patients do not have a true allergy but few have had it verified. Approximately 80% of patients with IgE-mediated penicillin allergy lose their sensitivity after 10 years. Several studies have been conducted denying the risk of sensitization following negative testing of penicillin allergy. Investigators have not had the same experience and have therefore decided to conduct a retrospective study review of 83 adult outpatients with a distant penicillin allergy label and evaluate outcomes of skin retesting six weeks following Drug Provocation Test and challenge.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental 83 adult outpatients at CHR Metz-Thionville with penicillin allergy label |
Other: Behavioral allergy testing protocol
skin tests followed by drug provocation test and skin retesting between 6 weeks and 6 months
|
Outcome Measures
Primary Outcome Measures
- efficacy of repeated skin testing [week 4]
verified efficacy of repeated skin testing 4 weeks or more after drug provocation test and challenge in distant penicillin allergic patients. The reagents used for skin testing were as follow: Penicillin G, Clamoxyl, Augmentin,Tienam, Histamine and Normal saline (negative control). A skin test producing a papule with a diameter greater then 3 mm is considered as positive.
Secondary Outcome Measures
- efficacy of allergy testing [Week 4]
efficacy of allergy testing in identifying penicillin hypersensitivity reactions. Patients were called to perform, once again skin testing because skin tests sooner could result in false negatives due to the temporary desensitized state.
Eligibility Criteria
Criteria
Inclusion Criteria:
- 18 years old
Exclusion Criteria:
-
Pregnancy
-
poorly controlled asthma and cardiovascular disease
-
use of drugs that interfere with testing and could not be stopped such as antihistamines, tricyclic antidepressants, antipsychotics, beta blockers, high dose oral glucocorticoids
-
Non-IgE mediated type of serious allergic reaction such as Stevens - Johnson syndrome, Toxic Epidermal Necrolysis, and Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | CHR Metz Thionville | Thionville | Moselle | France | 57100 |
Sponsors and Collaborators
- Centre Hospitalier Régional Metz-Thionville
Investigators
- Principal Investigator: Sebastien Lefevre, MD, CHR Metz Thionville
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2019-03Obs-CHRMT