Interleukin 20 and Periodontal Tisuue Destruction
Study Details
Study Description
Brief Summary
Periodontitis is an inflammatory disease that causes destruction of periodontal tissues. IL-20, on the other hand, is known as a potent angiogenic, chemotactic, and pro-inflammatory cytokine associated with various chronic inflammatory disorders. IL-20 has a significant role in the regulation of osteoclastogenesis and osteoblastogenesis. The aim of this study was to evaluate the effect of IL-20 on periodontal destruction.
In the study, a total of 60 participants were included, 30 of whom were systemically and periodontally healthy (control group) and 30 of whom were systemically healthy and had periodontitis (periodontitis group). GCF and serum samples were collected from the participants for biochemical analysis. ELISA method was used to determine IL-20, TNF-α, IL1β/IL-10, RANKL/OPG and MMP8 levels
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| control group (periodontally healthy) no attachment loss, probing pocket depth ≤ 3 mm, minimal bleeding on probing ≤ 10%, and no radiographic bone loss |
Other: biochemical analysis
GCF and serum samples were collected from the participants for biochemical analysis.
|
| periodontitis group interdental clinical attachment level ≥ 5 mm, probing pocket depth ≥ 6 mm, radiographic bone loss extending to the middle or apical thirds of the root, mid-crest defect, and a history of ≤4 teeth loss of periodontal origin |
Other: biochemical analysis
GCF and serum samples were collected from the participants for biochemical analysis.
|
Outcome Measures
Primary Outcome Measures
- concentration of biochemical findings in gingival crevicular fluid (GCF) [june 2022-june 2023]
IL-20, RANKL, OPG and RANKL/OPG values eveluated in GCF
- concentration of biochemical findings in serum [1 year]
IL-20, RANKL, OPG, RANKL/OPG, MMP-8, TNF-α, IL-1β, IL-10 and IL-1β/IL-10
Secondary Outcome Measures
- value of periodontal clinical parameters [1 year]
plaque index (PI) (Silness & Löe), gingival index (GI) (Silness & Löe) and bleeding on probing index (BOP) of all natural teeth of the patients
- value of periodontal clinical parameters were measured in mm [1 year]
probing pocket depth (PPD), clinical attachment loss (CAL) of all natural teeth of the patients
Eligibility Criteria
Criteria
Inclusion Criteria:
- The following criteria were required for inclusion: being systemically healthy, not smoking, not using antibiotics or systemic corticosteroids within the previous three months, not being pregnant or nursing, not having a chronic inflammatory disease, not receiving periodontal therapy within the previous six months, and possessing at least 20 teeth
Exclusion Criteria:
- smoking, using antibiotics or systemic corticosteroids within the previous three months, pregnant, receiving periodontal therapy within the previous six months
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Recep Tayyip Erdogan University | Rize | Turkey |
Sponsors and Collaborators
- Recep Tayyip Erdogan University
Investigators
- Principal Investigator: Yemenoglu, Recep Tayyip Erdogan University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- RecepTayyip ErdoganUniversity
- Recep Tayyip ErdoganUniversity