ATELHO: Perioperative Atelectasis in Orthopaedic Surgery: a Prospective Study

Sponsor
Eric Albrecht (Other)
Overall Status
Recruiting
CT.gov ID
NCT05384795
Collaborator
(none)
141
1
7.5
18.7

Study Details

Study Description

Brief Summary

This study aims at comparing a perioperative pulmonary atelectasis score, measured by pulmonary ultrasound, in patients operated undergoing orthopedic surgery under general anesthesia, spinal anesthesia or peripheral nerve block. The association between the atelectasis score and previously identified risk factors will be studied.

Condition or Disease Intervention/Treatment Phase
  • Other: Lung ultrasound

Detailed Description

Atelectasis is one of the most common pulmonary complications in the perioperative period, occurring in 85% to 90% of patients under general anesthesia. It can be responsible for hypoxemia and be associated with postoperative pulmonary complications such as pneumonia. The consequences are a prolongation of the hospital stay and an increase in mortality.

The appearance of perioperative atelectasis is mainly secondary to the induction of general anesthesia with an incidence up to 90%. The different causes are, for example, the administration of muscle relaxants, mechanical ventilation and the position of the patient.

In orthopedic surgery, many procedures are performed under spinal anesthesia or under peripheral nerve block. At present, there are no studies measuring the incidence of atelectasis in patients operated under these two techniques of locoregional anesthesia, with the exception of parturients undergoing cesarean section.

This study aims at comparing a perioperative pulmonary atelectasis score, measured by pulmonary ultrasound, in patients operated undergoing orthopedic surgery under general anesthesia, spinal anesthesia or peripheral nerve block. The association between the atelectasis score and previously identified risk factors will be studied.

Study Design

Study Type:
Observational
Anticipated Enrollment :
141 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
Perioperative Atelectasis in Patients Undergoing Orthopaedic Surgery: Prospective Cohort Study
Actual Study Start Date :
May 16, 2022
Anticipated Primary Completion Date :
Dec 31, 2022
Anticipated Study Completion Date :
Dec 31, 2022

Arms and Interventions

Arm Intervention/Treatment
General anesthesia

Other: Lung ultrasound
Lung atelectasis score

Spinal anesthesia

Other: Lung ultrasound
Lung atelectasis score

Peripheral nerve block

Other: Lung ultrasound
Lung atelectasis score

Outcome Measures

Primary Outcome Measures

  1. Lung atelectasis score [immediately after the surgery]

    Atelectasis score based on validated ultrasound quantification (comparing different anesthesia techniques)

Secondary Outcome Measures

  1. Lung atelectasis score [Four timepoints: at baseline, immediatly before surgery (after anesthesia induction), immediately after the surgery, and at the recovery room]

    Atelectasis score

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • Patients over the age of 18;

  • Patients scheduled for an elective operation at the Orthopedic Hospital of CHUV;

  • Signature of the study consent

Exclusion Criteria:
  • Thoracic deformities preventing the performance of pulmonary ultrasound (dressings, drains, fractures, etc.);

  • Refusal to participate;

  • Patient does not speak French.

  • Inability to discern

Contacts and Locations

Locations

Site City State Country Postal Code
1 Centre Hospitalier Universitaire Vaudois Lausanne Vaud Switzerland 1005

Sponsors and Collaborators

  • Eric Albrecht

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Eric Albrecht, Prof. Dr. med, Centre Hospitalier Universitaire Vaudois
ClinicalTrials.gov Identifier:
NCT05384795
Other Study ID Numbers:
  • CER-VD 2022-00712
First Posted:
May 20, 2022
Last Update Posted:
Jul 20, 2022
Last Verified:
Jul 1, 2022
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Jul 20, 2022