PVWMH: Periventricular White Matter Hyperintensities in Cerebral Amyloid Angiopathy and Hypertensive Arteriopathy
Study Details
Study Description
Brief Summary
White matter hyperintensities (WMH) are one of the small vessel disease-related MRI characteristics of both cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA). WMH tend to show a peri-basal ganglia pattern in HA, whereas a multiple subcortical spots pattern can be observed in CAA. Periventricular WMH (PVWMH) have been reported to be posterior predominant using a semiautomated segmentation method and logarithmic transformation, not used in daily clinical practice. In these studies including CAA patients, patients initially presented with haemorrhage-related symptoms. In another study analysing PVWMH and cerebral amyloid evidence in patients with mild cognitive impairment, frontal PVWMH burden was associated with high uptake on florbetapir-PET whereas parietal and occipital PVWMH burden was associated with low CSF-amyloid-beta.
The aim of this study is the descriptive comparative analysis of the distribution of PVWMH between CAA and HA patients with radiological tools available in daily practice.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| cerebral amyloid angiopathy Patient with cerebral amyloid angiopathy |
Other: None, pure observational study
None, pure observational study
|
| Hypertensive arteriopathy Patients with hypertensive arteriopathy |
Other: None, pure observational study
None, pure observational study
|
Outcome Measures
Primary Outcome Measures
- Distribution of PVWMH [Base line, Day 0]
Maximal distance between the outer PVWMH border and the border of the lateral ventricle (on the axis oriented at 90° to the border of the ventricle)
- Distribution of PVWMH - total PVWMH extent. [Base line, Day 0]
The sum of the PVWMH measurements around the four ventricles horns (i.e. bilateral anterior and posteriors horns) resulted in total PVWMH extent.
- Corpus callosum (CC) WMH [Base line, Day 0]
Distance between the border of the third ventricle and the outer border of the WMH on the rostro-caudal axis, resulting in anterior and posterior CC-PVWMH extent measurements.
- Corpus callosum (CC) WMH - total CC-PVWMH extent. [Base line, Day 0]
The sum of the anterior and posterior CC-PVWMH measurements resulted in the total CC-PVWMH extent.
- Ratios [base line, day 0]
Calcul of posterior/anterior ratios for both the PVWMH and CC-PVWMH
- Anterior PVWMH [Base line, Day 0]
Comparison of anterior PVWMH between CAA group and HA group.
- Posterior PVWMH [Base line, Day 0]
Comparison of posterior PVWMH between CAA group and HA group.
- Total PVWMH [Base line, Day 0]
Comparison of total PVWMH between CAA group and HA group.
- Posterior/anterior PVWMH ratio [Base line, Day 0]
Comparison of the posterior/anterior PVWMH ratio between CAA and HA groups.
- anterior CC-PVWMH [Base line, Day 0]
Comparison of anterior CC-PVWMH between CAA group and HA group.
- Posterior CC-PVWMH [Base line, Day 0]
Comparison of posterior CC-PVWMH between CAA group and HA group.
- Total PVWMH and posterior/anterior CC-PVWMH ratio [Base line, Day 0]
Comparison of total PVWMH and posterior/anterior CC-PVWMH ratio between CAA group and HA group.
Eligibility Criteria
Criteria
Inclusion Criteria:
CAA and HA patients, managed at Nîmes University Hospital between January 2015 and March 2022.
Exclusion Criteria:
CAA and HA patients, treated at the CHU of Nîmes between January 2015 and March 2022, not objecting to the use of their health data
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Centre Hospitalier Universitaire de Nīmes
Investigators
- Study Director: Anissa MEGZARI, Centre Hospitalier Universitaire de Nīmes
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- LOCAL/2022/DR-04