SIGEXPOSOME: Evaluation of Pesticide Exposure in the General Population
Study Details
Study Description
Brief Summary
An association has been suggested with several diseases including cancer and IARC has classified several pesticides as carcinogenic, probably carcinogenic. There is a need for a better characterisation of environmental pesticides exposures and identification of suitable biomarkers of exposure and effect. A better understanding of the impact of pesticide exposure on metabolomic, transcriptomic and epigenetic changes, is essential to strengthen epidemiological hypotheses on the association with several cancer types.
The main objective of the project is to validate a GIS (geographic information system) based method to assess environmental pesticide exposures, using environmental (contamination of housedust) and biological (blood and urine samples) measures. The project aims further to investigate a potential link between housedust contamination and biological measures in healthy non-smoking male residents and explore the impact of environmental pesticide exposure on metabolomics, transcriptomic and epigenetic parameters.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
The project involves a pilot phase involving repeated (twice) sampling in 20 male non-smoking volunteers living in the Beaujolais region (France) to perform appropriate calibrations for metabolomic, transcriptomic and epigenetic analyses. The main study will be conducted in a sample of 150 male non-smoking volunteers and 50 professional pesticides applicators from the same region (3 sampling periods).
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Professional pesticides A specific questionnaire with professional information about pesticide uses is added for this arm Questionnaire to collect domestic pesticide use, diet, household characteristics Dust sampling Blood sampling Urine sampling Hair sampling |
Biological: Questionnaire, blood, urine, hair and dust samplings
|
| Volunteers Questionnaire to collect domestic pesticide use, diet, household characteristics Dust sampling Blood sampling Urine sampling Hair sampling |
Biological: Questionnaire, blood, urine, hair and dust samplings
|
Outcome Measures
Primary Outcome Measures
- level of pesticide exposures [up to 2 years]
environmental, occupational and domestic exposures
Eligibility Criteria
Criteria
Inclusion Criteria:
- Non smokers in the last two years Living in the Beaujolais region (France) within 1000m of vignards Informed consent signed
Exclusion Criteria:
- Volunteers sharing the same households with professional applicators of pesticides
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Centre Leon Berard
- Cancéropôle Lyon Auvergne Rhône-Alpes
- International Agency for Research on Cancer
- Rovaltain Research Company
- Centre de rechercher en Cancérologie de Lyon
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- SIGEXPOSOME